{"id":"W2176377593","doi":"10.3389/fbioe.2015.00197","title":"Production of H5N1 Influenza Virus Matrix Protein 2 Ectodomain Protein Bodies in Tobacco Plants and in Insect Cells as a Candidate Universal Influenza Vaccine","year":2015,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Vector Institute; Poliomyelitis Research Foundation; South African Medical Research Council; National Research Foundation","keywords":"Ectodomain; Virology; Nicotiana benthamiana; Biology; Influenza A virus subtype H5N1; Viral matrix protein; Immunogenicity; Virus; Influenza vaccine; Antibody; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868793,0.000350373,0.0002626076,0.0001542866,0.0001636049,0.0002848762,0.0002409599,0.0003238027,0.0005358352],"category_scores_gemma":[0.00008448969,0.0001806854,0.0003559317,0.0002666004,0.0001756642,0.0002441669,0.0002748606,0.0004694741,0.0003573138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005277007,"about_ca_system_score_gemma":0.0002101054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409996,"about_ca_topic_score_gemma":0.001745603,"domain_scores_codex":[0.9999201,0.00001408357,0.000008913489,0.000016138,0.00002563223,0.00001512922],"domain_scores_gemma":[0.9999535,0.00000802757,0.00001308737,0.000007452622,0.000007767251,0.00001016514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002434053,0.000006951494,0.00005194013,0.00002343781,0.000002684442,0.00001698436,0.000008844254,0.00006930547,0.999481,0.00006336507,0.00001193967,0.0002392684],"study_design_scores_gemma":[0.00002444355,0.0002079446,0.001874266,0.000007176966,0.00002742353,0.0001243042,0.0000297128,0.002027832,0.9913084,0.00006927981,0.004292805,0.000006422773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854794,0.00138747,0.009862638,0.0001448678,0.00003958241,0.0001083287,0.001008709,0.0001016451,0.001867455],"genre_scores_gemma":[0.9782822,0.001206049,0.01265791,0.00005473082,0.00001067622,0.00006861785,0.002496234,0.00004051718,0.005183063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409996,"threshold_uncertainty_score":0.003828704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008242195538803801,"score_gpt":0.2220435492350943,"score_spread":0.2138013536962904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}