{"id":"W2176546276","doi":"10.1016/j.bmcl.2005.08.036","title":"Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; In vivo; Bronchoconstriction; Pharmacology; In vitro; Ovalbumin; Structure–activity relationship; Biological activity; Enzyme inhibitor; Biochemistry; Internal medicine; Immunology; Medicine; Asthma; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308581,0.0001746823,0.0002372351,0.00005276779,0.00005233215,0.0000114764,0.00009339446,0.0001739681,0.00002005633],"category_scores_gemma":[0.000104444,0.0001633971,0.00005858281,0.0002087707,0.0003206422,0.00004765406,0.00004649293,0.0000980107,3.418639e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003220054,"about_ca_system_score_gemma":0.00008227761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001691957,"about_ca_topic_score_gemma":0.000006152939,"domain_scores_codex":[0.9987811,0.00003645617,0.0005442163,0.0002898991,0.0002225311,0.0001257375],"domain_scores_gemma":[0.9989639,0.00001689029,0.0005162599,0.0002744074,0.0001747779,0.00005379281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00025795,0.00007009081,0.003588417,0.0001975786,0.0000546201,6.373951e-7,0.00008689288,0.001299669,0.9939794,0.0000078231,0.0003617585,0.00009514963],"study_design_scores_gemma":[0.0007792872,0.0000448543,0.01042036,0.00008207583,0.00006794537,0.00002999198,0.00007490448,0.0003128397,0.9879072,0.000004616344,0.0001367186,0.0001392575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924796,0.0004324465,0.005468519,0.00124205,0.000134219,0.0001437709,0.00007256676,0.00001109974,0.00001569596],"genre_scores_gemma":[0.9985608,0.0000885847,0.0004443542,0.00005720972,0.0003257393,0.000003570841,0.0003945056,0.00001621558,0.0001090546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006831943,"threshold_uncertainty_score":0.6663139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005202169468008323,"score_gpt":0.2006007533611719,"score_spread":0.1953985838931635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}