{"id":"W2176735297","doi":"10.1084/jem.20150603","title":"Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis","year":2015,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; American Heart Association; American Diabetes Association","keywords":"Inflammation; Proinflammatory cytokine; Endothelial dysfunction; Endothelium; Endothelial stem cell; Endothelial activation; Tumor necrosis factor alpha; Foam cell; Receptor; Signal transduction; Biology; Immunology; Cell biology; Lipoprotein; In vitro; Chemistry; Endocrinology; Cholesterol; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002473465,0.0002604624,0.0002870374,0.0002078387,0.0001068519,0.0003138863,0.0001855768,0.0002070386,0.0007153534],"category_scores_gemma":[0.0001835154,0.0001155305,0.0001673775,0.0001248252,0.0002257142,0.0001589586,0.0002196327,0.0005004194,0.0002331854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844726,"about_ca_system_score_gemma":0.0001903983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002284685,"about_ca_topic_score_gemma":0.000352916,"domain_scores_codex":[0.9998379,0.00004161247,0.00001925715,0.00002366334,0.00003549466,0.00004203109],"domain_scores_gemma":[0.9998974,0.00001300016,0.00002986307,0.00001233227,0.00001262022,0.00003478273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005331915,0.00003449418,0.0003322891,0.00005076277,0.000006800033,0.00006916046,0.00001597759,0.00003424475,0.9956392,0.0001504718,0.00005792057,0.003075572],"study_design_scores_gemma":[0.00009491217,0.0008329617,0.01114065,0.00001938846,0.00004895118,0.0005258313,0.00006089639,0.001024379,0.9820447,0.0002241479,0.003976492,0.000006612337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921325,0.003755189,0.002361003,0.0001859897,0.00004340385,0.00001848374,0.0001616896,0.00006206142,0.001279753],"genre_scores_gemma":[0.9958081,0.001471498,0.0009485601,0.00009561123,0.00002116022,0.00002094733,0.0001946262,0.0000122596,0.001427211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007153534,"threshold_uncertainty_score":0.002393067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150687352361706,"score_gpt":0.2506775652728698,"score_spread":0.2291706917492527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}