{"id":"W2176781048","doi":"10.1093/jnci/djv308","title":"Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer","year":2015,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Cancer Institute","keywords":"MSH6; Lynch syndrome; MLH1; Medicine; MSH2; Population; Internal medicine; Oncology; Receiver operating characteristic; Colorectal cancer; Cancer; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01461852,0.00125662,0.0009331546,0.002641031,0.0003117786,0.001309359,0.0008272443,0.0008172779,0.001186492],"category_scores_gemma":[0.03677988,0.000316775,0.001427111,0.0007464095,0.0004109759,0.0007463198,0.0008904953,0.001012179,0.0003724525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009704145,"about_ca_system_score_gemma":0.0009105942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004713421,"about_ca_topic_score_gemma":0.00216047,"domain_scores_codex":[0.9966504,0.002049032,0.0001764449,0.0004608143,0.0004587814,0.0002045906],"domain_scores_gemma":[0.9513199,0.04261706,0.002321026,0.0009261112,0.001978033,0.0008378911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00423311,0.0003486788,0.7536151,0.000139594,0.001307301,0.0002411253,0.0002760073,0.1862766,0.0003763722,0.0007322027,0.002229662,0.05022407],"study_design_scores_gemma":[0.0001680105,0.001010251,0.1099029,0.00007003025,0.0004033616,0.000331632,0.000148875,0.884226,0.0006003848,0.002547016,0.0005404012,0.00005111302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757459,0.0007826819,0.01996153,0.0006200714,0.0000567516,0.0001269157,0.0007350053,0.0003028991,0.001668201],"genre_scores_gemma":[0.9947186,0.0001343736,0.004164123,0.00005122359,0.00002557856,0.00005364128,0.0006532135,0.00001886275,0.0001803746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01461852,"threshold_uncertainty_score":0.07731104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136007073734585,"score_gpt":0.3809539082871021,"score_spread":0.2673532009136436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}