{"id":"W2176836693","doi":"10.1093/hmg/ddv413","title":"APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Alberta Innovates - Health Solutions; Canadian Institutes of Health Research; Alzheimer Society; Ara Parseghian Medical Research Foundation; University of Alberta; University of Chicago","keywords":"Endosome; Amyloid precursor protein; Biology; NPC1; Amyloid precursor protein secretase; Cell biology; Endocytic cycle; Intracellular; Biochemistry; Alzheimer's disease; Internal medicine; Endocytosis; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610753,0.0007208285,0.0007369782,0.0004325939,0.0002871565,0.0004262388,0.0002515254,0.0004662444,0.001919302],"category_scores_gemma":[0.0001667652,0.0003458857,0.0003480923,0.0002329905,0.0003759696,0.0003433785,0.0003587322,0.0008004348,0.0004290365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266889,"about_ca_system_score_gemma":0.0003291555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125493,"about_ca_topic_score_gemma":0.001191155,"domain_scores_codex":[0.9997728,0.0000357739,0.00003551755,0.00004568575,0.00005585089,0.0000542554],"domain_scores_gemma":[0.9997136,0.00002251633,0.00006468259,0.00002913222,0.00002530421,0.0001447014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009410449,0.0001424839,0.0002915716,0.00006133645,0.00001986518,0.0003321916,0.00003708572,0.00004881236,0.9969696,0.0001014003,0.00007569671,0.0009789898],"study_design_scores_gemma":[0.0001722423,0.003087512,0.02833594,0.0000373855,0.0001923179,0.003141228,0.0002311595,0.001811028,0.9565918,0.0004143389,0.005947361,0.00003784849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974376,0.0008168723,0.0004882324,0.00007683292,0.00003630216,0.00002232714,0.0002653064,0.00008456935,0.0007720275],"genre_scores_gemma":[0.99531,0.0008380593,0.0006173304,0.00005569716,0.00002142749,0.00005048133,0.0003818182,0.0000347576,0.002690364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919302,"threshold_uncertainty_score":0.006420672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04662615445088087,"score_gpt":0.3260446676110488,"score_spread":0.2794185131601679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}