{"id":"W2176918678","doi":"10.1371/journal.pone.0138078","title":"Co-Administration of Cholesterol-Lowering Probiotics and Anthraquinone from Cassia obtusifolia L. Ameliorate Non-Alcoholic Fatty Liver","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Specialized Research Fund for the Doctoral Program of Higher Education of China; National Key Research and Development Program of China; National High-tech Research and Development Program; National Natural Science Foundation of China","keywords":"Cholesterol 7 alpha-hydroxylase; Farnesoid X receptor; Fatty liver; Cholesterol; Endocrinology; Internal medicine; Occludin; Liver X receptor; Peroxisome proliferator-activated receptor; Gut flora; Pharmacology; Liver X receptor alpha; Sterol regulatory element-binding protein; Biology; Chemistry; Sterol; Receptor; Biochemistry; Medicine; Tight junction; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083964,0.0004716977,0.0007403578,0.0004209663,0.000158495,0.0001768908,0.0001681591,0.0002717193,0.001015878],"category_scores_gemma":[0.0001355375,0.0001414328,0.0003112012,0.0002129651,0.0001785214,0.0002606465,0.0002805566,0.00071109,0.0001480687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000109657,"about_ca_system_score_gemma":0.0002427637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006571891,"about_ca_topic_score_gemma":0.001178466,"domain_scores_codex":[0.9999229,0.00001418092,0.0000112231,0.00001476009,0.00001614651,0.00002093463],"domain_scores_gemma":[0.9999125,0.000007735198,0.00002878259,0.000006731894,0.00001274292,0.00003152704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007160678,0.001555302,0.0008984474,0.0006099815,0.00008021279,0.000230016,0.00006218637,0.0001523201,0.9653521,0.00007393828,0.0001813935,0.02364353],"study_design_scores_gemma":[0.001143189,0.03582257,0.02940709,0.0001472718,0.0006332343,0.0007370909,0.0003087424,0.001765678,0.9205194,0.0002577028,0.00922168,0.00003637165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942675,0.003771766,0.0007847889,0.0001947017,0.00008900493,0.00003829559,0.0001321598,0.00008653961,0.0006352721],"genre_scores_gemma":[0.9933019,0.002499172,0.001625546,0.0001667102,0.00003090822,0.00004658078,0.0002188036,0.00001572093,0.002094685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015878,"threshold_uncertainty_score":0.003398418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09192668139917837,"score_gpt":0.287065074089682,"score_spread":0.1951383926905036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}