{"id":"W2177095489","doi":"10.1128/aac.00932-15","title":"Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Ribavirin; Virology; Hepatitis C virus; Pegylated interferon; Population; Biology; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004015746,0.0002738219,0.001011726,0.0004163214,0.0002251455,0.0005648634,0.0002599246,0.0007484886,0.0009630604],"category_scores_gemma":[0.007057213,0.0002805644,0.0009398521,0.0006418637,0.0002426281,0.0006617725,0.0002150941,0.0007711561,0.0001080611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082634,"about_ca_system_score_gemma":0.000261934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000406502,"about_ca_topic_score_gemma":0.0007322308,"domain_scores_codex":[0.9972759,0.001234879,0.0003680303,0.00054105,0.0003868958,0.0001932853],"domain_scores_gemma":[0.9923514,0.003250214,0.00312412,0.0003652885,0.000397638,0.0005114486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03561904,0.0003781034,0.9366415,0.0001677064,0.003237883,0.0003217084,0.0001700108,0.0003959466,0.006617232,0.00003337348,0.0002506799,0.0161668],"study_design_scores_gemma":[0.0004825352,0.004966021,0.9921469,0.0000185258,0.0007486821,0.0003864061,0.00004567173,0.0003037246,0.0006397035,0.00003683122,0.0002138496,0.00001114285],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970087,0.002252552,0.0001375355,0.00003389916,0.000009475523,0.00003588905,0.0002199253,0.000005670247,0.0002963379],"genre_scores_gemma":[0.99941,0.0001416395,0.00006938685,0.00003607636,0.00001180648,0.00002030401,0.0002254476,0.000002019111,0.00008330242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004015746,"threshold_uncertainty_score":0.02123755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05346612936488404,"score_gpt":0.3616382716205732,"score_spread":0.3081721422556892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}