{"id":"W2177096160","doi":"10.1016/j.bmcl.2003.10.068","title":"Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum","funders":"","keywords":"Subgenomic mRNA; NS5B; Chemistry; Polymerase; Hepatitis C virus; Virology; RNA polymerase; RNA-dependent RNA polymerase; Enzyme; Virus; RNA; Hepacivirus; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004275969,0.0003157229,0.0006103181,0.0001229475,0.00007125582,0.00001805158,0.0002748161,0.0001890008,0.0001360765],"category_scores_gemma":[0.0005783751,0.0002889298,0.0001470449,0.000356854,0.0007701532,0.0001433565,0.0001533351,0.0004312238,0.00001383968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179372,"about_ca_system_score_gemma":0.0005133628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007628889,"about_ca_topic_score_gemma":0.000005109732,"domain_scores_codex":[0.9971123,0.00004686849,0.0008347321,0.000661438,0.0008787345,0.0004659734],"domain_scores_gemma":[0.9981308,0.00009072691,0.0003109974,0.001010227,0.0001123629,0.0003448884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001953656,0.0001488907,0.02060357,0.0006004415,0.0001446907,0.0001311383,0.0003153278,0.000001013304,0.9733093,0.00001064043,0.0003883879,0.004151205],"study_design_scores_gemma":[0.00203588,0.0001392638,0.02402444,0.0006813352,0.0001669611,0.0001078491,0.0002316579,0.000004268675,0.9720293,0.00002720816,0.0003286071,0.000223245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852392,0.00172176,0.00003980326,0.01170689,0.00009922788,0.00036675,0.00004112134,0.00004743061,0.0007378394],"genre_scores_gemma":[0.9969546,0.0005804044,0.0001336924,0.001554735,0.0005104032,0.00002390829,0.0000780355,0.00005789655,0.0001063395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0117154,"threshold_uncertainty_score":0.9999563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201152207787342,"score_gpt":0.2571372446555651,"score_spread":0.2451257225776917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}