{"id":"W2177242282","doi":"10.1089/104303402760372918","title":"<i>In Utero</i> Injection of <i>α</i> -L-Iduronidase-Carrying Retrovirus in Canine Mucopolysaccharidosis Type I: Infection of Multiple Tissues and Neonatal Gene Expression","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; University of Guelph; Sunnybrook Health Science Centre","funders":"","keywords":"In utero; Biology; Mucopolysaccharidosis; Genetic enhancement; Transduction (biophysics); Mucopolysaccharidosis type I; Transgene; Gene expression; Lysosomal storage disease; Viral vector; Gene; Enzyme replacement therapy; Molecular biology; Fetus; Pathology; Genetics; Enzyme; Medicine; Recombinant DNA; Disease; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003308532,0.0003774783,0.000266862,0.0003578472,0.0002284879,0.0003462798,0.0004199753,0.000458574,0.000884966],"category_scores_gemma":[0.0002745853,0.0002275789,0.0002616479,0.0001444381,0.0003783029,0.0003055411,0.0002892574,0.0008652757,0.0003982919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004641772,"about_ca_system_score_gemma":0.0003420209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001470599,"about_ca_topic_score_gemma":0.001486428,"domain_scores_codex":[0.9996443,0.0000692914,0.00004882201,0.0001089914,0.00006815499,0.00006042552],"domain_scores_gemma":[0.9997371,0.00006439655,0.00007610073,0.00003959743,0.00002045645,0.00006229349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107995,0.00005874113,0.0002625672,0.00003124142,0.000006050185,0.0001579937,0.0000478414,0.00005660328,0.9971576,0.0002189922,0.00007517455,0.001819159],"study_design_scores_gemma":[0.00001757808,0.0006728409,0.001798777,0.000009115492,0.00002582953,0.001083871,0.0000366576,0.0007846561,0.9929831,0.00003523307,0.002547246,0.000005216038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873367,0.001132277,0.007522977,0.0001839823,0.0001115294,0.0001814907,0.0004521076,0.0002217063,0.002857124],"genre_scores_gemma":[0.9786898,0.001049182,0.0133389,0.0001184534,0.00003946804,0.0001760098,0.001179329,0.0001309269,0.005277866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470599,"threshold_uncertainty_score":0.003367841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026777604859801,"score_gpt":0.2926626125726882,"score_spread":0.2623948365240902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}