{"id":"W2177242282","doi":"10.1089/104303402760372918","title":"<i>In Utero</i> Injection of <i>α</i> -L-Iduronidase-Carrying Retrovirus in Canine Mucopolysaccharidosis Type I: Infection of Multiple Tissues and Neonatal Gene Expression","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; University of Guelph; Sunnybrook Health Science Centre","funders":"","keywords":"In utero; Biology; Mucopolysaccharidosis; Genetic enhancement; Transduction (biophysics); Mucopolysaccharidosis type I; Transgene; Gene expression; Lysosomal storage disease; Viral vector; Gene; Enzyme replacement therapy; Molecular biology; Fetus; Pathology; Genetics; Enzyme; Medicine; Recombinant DNA; Disease; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002495513,0.0001733536,0.0002389996,0.0002178103,0.00005451639,0.00000990568,0.0001260137,0.0001524056,0.0001157089],"category_scores_gemma":[0.00001945459,0.0001778571,0.00005051185,0.000243889,0.00009280609,0.00001704412,0.00006268582,0.0001304858,0.000001801221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003323318,"about_ca_system_score_gemma":0.0000211625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065195,"about_ca_topic_score_gemma":0.001665758,"domain_scores_codex":[0.9987404,0.0001560208,0.0003403671,0.000346543,0.000179037,0.0002376634],"domain_scores_gemma":[0.9993938,0.00001487212,0.0001337179,0.0003323577,0.00007541863,0.00004981906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001002111,0.0001364924,0.02545412,0.00002108468,0.00002220055,0.000005640242,0.0003877764,0.0002406689,0.9678411,0.000001503378,0.0001126983,0.004774533],"study_design_scores_gemma":[0.002043039,0.002891416,0.003106939,0.00002818536,0.000003047902,0.00001581542,0.00002129346,0.0001550728,0.9912859,0.00002670792,0.0002677151,0.0001549197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925389,0.006982671,0.00005683747,0.00002000099,0.00007523096,0.0002692235,0.00001365692,0.00000918641,0.00003434854],"genre_scores_gemma":[0.9934707,0.005974314,0.0001776245,0.00007422269,0.0001054436,0.00002174186,0.00003684831,0.00003521584,0.0001038907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02344467,"threshold_uncertainty_score":0.7252802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026777604859801,"score_gpt":0.2926626125726882,"score_spread":0.2623948365240902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}