{"id":"W2177323728","doi":"10.1016/s0960-894x(03)00042-8","title":"Discovery of a potent and selective agonist of the prostaglandin EP4 receptor","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Agonist; Prostaglandin E2 receptor; Receptor; Potency; Prostaglandin; Pharmacology; Stereochemistry; Chemical synthesis; Biochemistry; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097455,0.0001800783,0.0003721661,0.00002510525,0.00005528922,0.000005472756,0.00009204543,0.0000974029,0.00004108309],"category_scores_gemma":[0.0004272424,0.0001151218,0.00009350306,0.0002204044,0.0004043883,0.00003831026,0.00003134723,0.0002490751,0.000001579931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009377605,"about_ca_system_score_gemma":0.0002135542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002086366,"about_ca_topic_score_gemma":8.552688e-7,"domain_scores_codex":[0.9987913,0.00005442129,0.0003156764,0.0002331503,0.0003795945,0.0002258625],"domain_scores_gemma":[0.9992588,0.00007561439,0.0002156234,0.0002840607,0.00006383211,0.0001020923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459736,0.00006002604,0.02967261,0.0006592349,0.00007467034,0.00001382473,0.0003679024,7.493358e-8,0.9671322,0.00001919689,0.001728241,0.0001261238],"study_design_scores_gemma":[0.001408531,0.00008789102,0.01917081,0.0003533112,0.0001452962,0.0001469846,0.000279648,0.000001928131,0.9776825,0.000006866687,0.0006094567,0.0001067235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968343,0.00039899,0.0000437109,0.00164179,0.0001868867,0.0003253425,0.00001377194,0.00001236829,0.0005428747],"genre_scores_gemma":[0.9990943,0.00003686597,0.00006242318,0.0004277218,0.0001673986,0.000009475171,0.000007994267,0.00002016557,0.0001736183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01055043,"threshold_uncertainty_score":0.4694532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005161414637041062,"score_gpt":0.2017075447798815,"score_spread":0.1965461301428405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}