{"id":"W2177532767","doi":"10.1186/s40478-015-0255-6","title":"Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis","year":2015,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; King's College London; Biotechnology and Biological Sciences Research Council; Home Office; Wellcome Trust; Wellcome","keywords":"Tamoxifen; Cholesterol; Medicine; Pharmacology; Neuroscience; Chemistry; Endocrinology; Internal medicine; Biology; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718292,0.0004038044,0.0002665744,0.000283238,0.0001492071,0.0002346024,0.0003098324,0.0003438403,0.001694205],"category_scores_gemma":[0.000123985,0.00008572816,0.0002809247,0.0001622839,0.0002745478,0.0002135069,0.0001920463,0.0004237133,0.0004438738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262667,"about_ca_system_score_gemma":0.0002224802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002944893,"about_ca_topic_score_gemma":0.0005904281,"domain_scores_codex":[0.9998571,0.00002492691,0.00002458757,0.00002903751,0.00003167882,0.0000326726],"domain_scores_gemma":[0.9998689,0.00001914013,0.0000540635,0.0000191229,0.00001565226,0.00002310265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000096255,0.00002340349,0.0001734955,0.00008230889,0.000008826611,0.00008097928,0.00001053145,0.00001760057,0.9974216,0.00009839076,0.00006166727,0.001924949],"study_design_scores_gemma":[0.00003027762,0.0006340735,0.002272331,0.00002137238,0.0000353396,0.0003331264,0.00002702502,0.0001634348,0.9917279,0.00005563895,0.004695538,0.000003890376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776046,0.007489922,0.009777331,0.0005264258,0.0001943266,0.0001486084,0.000832387,0.0003668832,0.003059498],"genre_scores_gemma":[0.9798281,0.007487799,0.007099309,0.0002243732,0.00005202388,0.0001860894,0.000833508,0.00005064351,0.004238275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694205,"threshold_uncertainty_score":0.005667686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05147914140177418,"score_gpt":0.2785987986430183,"score_spread":0.2271196572412441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}