{"id":"W2177538943","doi":"10.1038/ng.3437","title":"Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":424,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Centre Hospitalier de l’Université de Montréal","funders":"National Institute on Aging; Medical Research Council; U.S. Public Health Service; National Institutes of Health; Heinz Nixdorf Stiftung; H. Lundbeck A/S; National Center for Research Resources; Diabetesliitto; Deutsche Forschungsgemeinschaft; Svenska Läkaresällskapet; Novo Nordisk Fonden; Hjerteforeningen; Magnus Bergvalls Stiftelse; Opetus- ja Kulttuuriministeriö; Sydäntutkimussäätiö; Augustinus Fonden; National Human Genome Research Institute; Danmarks Frie Forskningsfond; Vetenskapsrådet; Stockholms Läns Landsting; Royal Swedish Academy of Sciences; Diabetes UK; Etelä-Pohjanmaan Sairaanhoitopiiri; Signe ja Ane Gyllenbergin Säätiö; Kuopion Yliopistollinen Sairaala; National Institute of Diabetes and Digestive and Kidney Diseases; Norwegian Institute of Public Health; Stiftelsen för Gamla Tjänarinnor; Helsingin ja Uudenmaan Sairaanhoitopiiri; Knut och Alice Wallenbergs Stiftelse; Paavo Nurmen Säätiö; Novo Nordisk; Hjärt-Lungfonden; Foundation for Cardiovascular Research; Pirkanmaan Sairaanhoitopiiri; Finska Läkaresällskapet; National Cancer Institute; Lundbeckfonden; National Heart, Lung, and Blood Institute; Bundesministerium für Gesundheit; School of Medicine, Boston University; European Commission; British Heart Foundation; Bundesministerium für Bildung und Forschung; Varsinais-Suomen Sairaanhoitopiiri; National Institute for Health and Care Research; Swedish e-Science Research Centre; Norges Forskningsråd; Stiftelsen för Strategisk Forskning; Erasmus Medisch Centrum; Helmholtz Zentrum München; Kela; ZonMw; Diabetestutkimussäätiö; Wellcome Trust; Karolinska Institutet; European Regional Development Fund; Terveyden ja hyvinvoinnin laitos","keywords":"Biology; Genetics; Annotation; Type 2 diabetes; Computational biology; Genome-wide association study; Evolutionary biology; Single-nucleotide polymorphism; Diabetes mellitus; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003833523,0.0002178468,0.0002311704,0.00005267438,0.0001120477,0.00002014756,0.0001534883,0.0006069941,0.00002180747],"category_scores_gemma":[0.0003945715,0.0002144711,0.00005260579,0.0001296501,0.00008653006,0.000002301469,0.0002462202,0.0001850351,0.00002511776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006103992,"about_ca_system_score_gemma":0.00009821328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008755411,"about_ca_topic_score_gemma":0.0002283791,"domain_scores_codex":[0.9985674,0.0001302805,0.0003001405,0.0004960844,0.0001409041,0.0003652176],"domain_scores_gemma":[0.9990007,0.00002822577,0.0001427926,0.0003708124,0.0002905857,0.0001669298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004302074,0.00003985121,0.61756,0.00002735272,0.00009345554,0.000002059528,0.000141618,0.00101169,0.3643255,0.00003719219,0.01292904,0.003789221],"study_design_scores_gemma":[0.001012583,0.0008079956,0.9386783,0.000006875492,0.00007535584,0.00002385197,0.0001315604,0.001474827,0.02385669,0.003818457,0.02960913,0.000504422],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903401,0.007413965,0.001018512,0.0002750393,0.0004377861,0.0002681818,0.00003247774,0.00001813282,0.0001958247],"genre_scores_gemma":[0.9758611,0.0004486834,0.02205093,0.0005498042,0.0003325341,0.00001650256,0.0003041765,0.00003061839,0.0004056844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3404689,"threshold_uncertainty_score":0.8745878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484815833429496,"score_gpt":0.2540216385815101,"score_spread":0.2391734802472151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}