{"id":"W2177538943","doi":"10.1038/ng.3437","title":"Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":424,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Centre Hospitalier de l’Université de Montréal","funders":"National Institute on Aging; Medical Research Council; U.S. Public Health Service; National Institutes of Health; Heinz Nixdorf Stiftung; H. Lundbeck A/S; National Center for Research Resources; Diabetesliitto; Deutsche Forschungsgemeinschaft; Svenska Läkaresällskapet; Novo Nordisk Fonden; Hjerteforeningen; Magnus Bergvalls Stiftelse; Opetus- ja Kulttuuriministeriö; Sydäntutkimussäätiö; Augustinus Fonden; National Human Genome Research Institute; Danmarks Frie Forskningsfond; Vetenskapsrådet; Stockholms Läns Landsting; Royal Swedish Academy of Sciences; Diabetes UK; Etelä-Pohjanmaan Sairaanhoitopiiri; Signe ja Ane Gyllenbergin Säätiö; Kuopion Yliopistollinen Sairaala; National Institute of Diabetes and Digestive and Kidney Diseases; Norwegian Institute of Public Health; Stiftelsen för Gamla Tjänarinnor; Helsingin ja Uudenmaan Sairaanhoitopiiri; Knut och Alice Wallenbergs Stiftelse; Paavo Nurmen Säätiö; Novo Nordisk; Hjärt-Lungfonden; Foundation for Cardiovascular Research; Pirkanmaan Sairaanhoitopiiri; Finska Läkaresällskapet; National Cancer Institute; Lundbeckfonden; National Heart, Lung, and Blood Institute; Bundesministerium für Gesundheit; School of Medicine, Boston University; European Commission; British Heart Foundation; Bundesministerium für Bildung und Forschung; Varsinais-Suomen Sairaanhoitopiiri; National Institute for Health and Care Research; Swedish e-Science Research Centre; Norges Forskningsråd; Stiftelsen för Strategisk Forskning; Erasmus Medisch Centrum; Helmholtz Zentrum München; Kela; ZonMw; Diabetestutkimussäätiö; Wellcome Trust; Karolinska Institutet; European Regional Development Fund; Terveyden ja hyvinvoinnin laitos","keywords":"Biology; Genetics; Annotation; Type 2 diabetes; Computational biology; Genome-wide association study; Evolutionary biology; Single-nucleotide polymorphism; Diabetes mellitus; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001395791,0.0006619447,0.0005630922,0.003270882,0.0007167336,0.001485514,0.001022005,0.001053256,0.004523879],"category_scores_gemma":[0.002733225,0.0005628309,0.001154206,0.002313662,0.0006320963,0.0005015905,0.00108152,0.001421459,0.0006322535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420532,"about_ca_system_score_gemma":0.0004194609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002105666,"about_ca_topic_score_gemma":0.003313133,"domain_scores_codex":[0.9990131,0.0002680237,0.00008464761,0.0003343194,0.0001708383,0.0001289536],"domain_scores_gemma":[0.9972186,0.001513114,0.0005082388,0.0004079026,0.0001464873,0.0002056732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003097511,0.0006313522,0.4189189,0.000698498,0.001583999,0.005280516,0.001266038,0.003567137,0.439108,0.01615065,0.002980601,0.1067168],"study_design_scores_gemma":[0.0004755793,0.0002702958,0.875628,0.0002539023,0.001943595,0.004481829,0.000761267,0.00772727,0.05465868,0.03104122,0.02263266,0.0001257206],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480967,0.002769185,0.03818019,0.001134981,0.0001951481,0.00006418091,0.004027577,0.000351948,0.005180061],"genre_scores_gemma":[0.9752319,0.001035705,0.01877734,0.0004687183,0.0001560591,0.00005225996,0.002442477,0.0001429783,0.001692601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004523879,"threshold_uncertainty_score":0.01513386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484815833429496,"score_gpt":0.2540216385815101,"score_spread":0.2391734802472151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}