{"id":"W2177542975","doi":"10.1016/j.celrep.2015.10.041","title":"ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute on Aging; National Medical Research Council; Cancer Council NSW; National Health and Medical Research Council; Ian Potter Foundation; Canadian Institutes of Health Research; Australian Cancer Research Foundation","keywords":"Telomerase; Telomere; Cell biology; Biology; Telomerase RNA component; DNA damage; Shelterin; Phosphorylation; Telomere-binding protein; Molecular biology; Telomerase reverse transcriptase; DNA; Genetics; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500888,0.0002360802,0.0001126037,0.0002848781,0.0001634069,0.0003838772,0.0001177263,0.0001576939,0.00111503],"category_scores_gemma":[0.0001470558,0.0001483054,0.0001717707,0.0001545572,0.0001252527,0.0002549007,0.0002281801,0.0002279418,0.0003639991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083397,"about_ca_system_score_gemma":0.000153042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000251793,"about_ca_topic_score_gemma":0.0004011931,"domain_scores_codex":[0.999904,0.00001384761,0.000009123492,0.00002243265,0.00001905211,0.00003141072],"domain_scores_gemma":[0.9999431,0.000007069924,0.00002073566,0.000005169642,0.000007780894,0.00001613124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002741092,0.00002051601,0.001170418,0.00003440903,0.000006158566,0.0001169493,0.00002915423,0.0001397516,0.992213,0.0002983162,0.00009247293,0.005604773],"study_design_scores_gemma":[0.00004761815,0.0003029444,0.05591612,0.00001862429,0.00004423448,0.0009012527,0.0001071378,0.002642686,0.9323005,0.0006808114,0.007024023,0.00001406251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912005,0.005367718,0.001393563,0.0001288412,0.00002521942,0.00001061953,0.0002684682,0.0001024911,0.001502652],"genre_scores_gemma":[0.9959025,0.001563074,0.0006770495,0.00002809087,0.00001107592,0.000008556961,0.000188099,0.000007923501,0.001613792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00111503,"threshold_uncertainty_score":0.003730118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08513490257579835,"score_gpt":0.3205769734283228,"score_spread":0.2354420708525244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}