{"id":"W2177645608","doi":"10.1161/atvbaha.115.306035","title":"Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Fibrinolysis; Plasmin; Fibrin; Sepsis; Coagulation; Plasminogen activator; Lysis; Neutrophil extracellular traps; Medicine; Immunology; Chemistry; Inflammation; Internal medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002757498,0.0003836438,0.000277119,0.0003183897,0.0001136575,0.0002606326,0.000202798,0.0004831167,0.001556785],"category_scores_gemma":[0.0006029322,0.0001114929,0.000235929,0.0001571693,0.0003451388,0.0001921639,0.0002167421,0.0004678238,0.000260054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349292,"about_ca_system_score_gemma":0.0002070217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000218016,"about_ca_topic_score_gemma":0.0001935921,"domain_scores_codex":[0.9997857,0.00006549504,0.00002350249,0.00003793593,0.00005113261,0.00003626789],"domain_scores_gemma":[0.9997235,0.00008953483,0.00008916332,0.00002155839,0.00003733705,0.00003897427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004250295,0.00004742295,0.0002873914,0.0001281891,0.00001127988,0.00004373609,0.00001877737,0.00007502625,0.9965637,0.00003599466,0.00002862288,0.002334805],"study_design_scores_gemma":[0.00008244022,0.002848679,0.009169058,0.00004339346,0.00003621216,0.0004263126,0.00003033428,0.0007501391,0.985085,0.0001080805,0.001410238,0.00001021793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988622,0.006514614,0.003801728,0.0001624983,0.00006524379,0.00003977853,0.0002280068,0.00006917607,0.0004968124],"genre_scores_gemma":[0.9942495,0.002015866,0.002289462,0.0001059359,0.00002712996,0.0000566558,0.0004304381,0.000007732577,0.0008173836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001556785,"threshold_uncertainty_score":0.005207956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0270936886490086,"score_gpt":0.2443481308200241,"score_spread":0.2172544421710155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}