{"id":"W2177786913","doi":"10.1021/jo049288r","title":"Potent Inhibitors of the Hepatitis C Virus NS3 Protease:  Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics","year":2004,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Hepatitis C virus; NS2-3 protease; Protease; Enzyme; Chemistry; Ligand (biochemistry); Virology; Hepatocellular carcinoma; Substrate (aquarium); Biochemistry; Virus; Hepacivirus; Stereochemistry; Biology; Receptor; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120883,0.000305367,0.0002509922,0.0001112858,0.0001055887,0.0002563051,0.0002982626,0.0002304727,0.0008163241],"category_scores_gemma":[0.0001490583,0.0001469151,0.0001514778,0.00008677046,0.0001150334,0.0002095773,0.00016221,0.0002513986,0.0003049413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002345892,"about_ca_system_score_gemma":0.0001709949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001985655,"about_ca_topic_score_gemma":0.0005016135,"domain_scores_codex":[0.9999456,0.00001187867,0.000004721127,0.00001098679,0.0000154397,0.00001128541],"domain_scores_gemma":[0.9999524,0.000007227731,0.00001625039,0.000003630663,0.000005086008,0.00001536424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000416677,0.0001407335,0.0003127775,0.0003341501,0.00003173818,0.0003071698,0.00011042,0.01138467,0.9568897,0.003616983,0.0005054834,0.02594952],"study_design_scores_gemma":[0.0001565371,0.002269086,0.0006826299,0.00002654488,0.00004395664,0.0004595723,0.00002822238,0.01004021,0.9607481,0.0004499023,0.02506351,0.00003166265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.941635,0.01303927,0.03230634,0.0002490129,0.0001124889,0.000404915,0.0006672732,0.0003380686,0.01124768],"genre_scores_gemma":[0.9674933,0.007350206,0.02032308,0.0001242601,0.00002376282,0.0001925702,0.0004163665,0.00003013755,0.004046353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008163241,"threshold_uncertainty_score":0.002730846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563409119712336,"score_gpt":0.2477130842958726,"score_spread":0.2320789930987492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}