{"id":"W2177786913","doi":"10.1021/jo049288r","title":"Potent Inhibitors of the Hepatitis C Virus NS3 Protease:  Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics","year":2004,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Hepatitis C virus; NS2-3 protease; Protease; Enzyme; Chemistry; Ligand (biochemistry); Virology; Hepatocellular carcinoma; Substrate (aquarium); Biochemistry; Virus; Hepacivirus; Stereochemistry; Biology; Receptor; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008665393,0.0001528061,0.0003949961,0.0000403868,0.0000724213,0.0000110407,0.0002974446,0.0001181305,0.0001744237],"category_scores_gemma":[0.0006897897,0.00008944475,0.0001348489,0.000264435,0.0003577288,0.00004377819,0.00004673213,0.0004786725,0.000001389613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001575262,"about_ca_system_score_gemma":0.0008705014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001736872,"about_ca_topic_score_gemma":0.00002254252,"domain_scores_codex":[0.9982548,0.0001177269,0.0006338445,0.0001009431,0.0006866548,0.0002059719],"domain_scores_gemma":[0.9984515,0.0002647228,0.0005067426,0.0003440776,0.0002783347,0.0001545809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004556258,0.0002246909,0.007860395,0.0004021763,0.0001176793,0.00004332983,0.0001737677,0.000114669,0.9894494,5.527173e-7,0.00006259502,0.001095125],"study_design_scores_gemma":[0.001669565,0.0001472362,0.006949964,0.0007423755,0.0002288384,0.0003343867,0.00007726405,0.00003981981,0.9896388,0.00007196741,0.00002417247,0.00007559231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970235,0.0005820333,0.0006155127,0.001299176,0.00002884206,0.000324552,0.00001945635,0.000005114804,0.0001018566],"genre_scores_gemma":[0.9981365,0.001015993,0.0006723243,0.00004002876,0.00007743786,0.000003012371,5.945296e-7,0.00002718476,0.00002692698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259147,"threshold_uncertainty_score":0.3647451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563409119712336,"score_gpt":0.2477130842958726,"score_spread":0.2320789930987492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}