{"id":"W2177877486","doi":"10.1081/ncn-120022728","title":"Nucleobase Modified Peptide Nucleic Acid","year":2003,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleobase; Peptide nucleic acid; Nucleic acid; Uracil; Chemistry; Monomer; Cytosine; Peptide; Combinatorial chemistry; Nucleic acid analogue; Coupling reaction; DNA; Stereochemistry; Ring (chemistry); Organic chemistry; Nucleic acid thermodynamics; Biochemistry; Catalysis; Base sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479692,0.0003664311,0.0002192557,0.0001491496,0.0001576248,0.0001965041,0.0002809222,0.0004030043,0.002686773],"category_scores_gemma":[0.0002232173,0.0001403849,0.0001289703,0.0001299592,0.0001388035,0.0002304335,0.0002278064,0.0004983302,0.001249328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984058,"about_ca_system_score_gemma":0.0001678173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002189037,"about_ca_topic_score_gemma":0.0003872055,"domain_scores_codex":[0.9998698,0.00002051841,0.000007901858,0.00004403815,0.0000350098,0.00002263811],"domain_scores_gemma":[0.9999096,0.00001560601,0.00002094022,0.00001211181,0.00001697737,0.00002470445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002330654,0.000006130752,0.00001489532,0.00003079267,0.000002643857,0.00005428136,0.00001043856,0.00004830596,0.9982796,0.0001562281,0.00002576981,0.001347715],"study_design_scores_gemma":[0.000007491039,0.0001053936,0.0001694282,0.000003016818,0.000005382909,0.0001752553,0.000002578889,0.0001897521,0.9953348,0.0000321859,0.003970564,0.000004293242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519081,0.005249525,0.02938957,0.0001526938,0.0002272832,0.0001855247,0.0004477804,0.0004262011,0.01201336],"genre_scores_gemma":[0.9549994,0.002461012,0.02691164,0.0001564944,0.00003371253,0.0001218242,0.0006822983,0.00008628012,0.01454727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002686773,"threshold_uncertainty_score":0.008988142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133989025679938,"score_gpt":0.2513813790520937,"score_spread":0.2400414887952943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}