{"id":"W2177877486","doi":"10.1081/ncn-120022728","title":"Nucleobase Modified Peptide Nucleic Acid","year":2003,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nucleobase; Peptide nucleic acid; Nucleic acid; Uracil; Chemistry; Monomer; Cytosine; Peptide; Combinatorial chemistry; Nucleic acid analogue; Coupling reaction; DNA; Stereochemistry; Ring (chemistry); Organic chemistry; Nucleic acid thermodynamics; Biochemistry; Catalysis; Base sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007843667,0.0009774832,0.0008116837,0.0003121961,0.0006764171,0.0002514616,0.0008737375,0.0006301634,0.0001705762],"category_scores_gemma":[0.0006487649,0.0009479139,0.0007330431,0.0006898924,0.0007078068,0.00006386888,0.0003237716,0.0005311624,0.0002577801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001248906,"about_ca_system_score_gemma":0.0001373763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003402396,"about_ca_topic_score_gemma":0.00005407229,"domain_scores_codex":[0.9949791,0.000364097,0.001011752,0.001653007,0.0006543918,0.001337642],"domain_scores_gemma":[0.9966788,0.0000498118,0.0004345198,0.001926628,0.0003505742,0.0005597161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002217928,0.0003789926,0.002464451,0.00004510451,0.0002794734,0.00005720583,0.0000936031,0.00006428688,0.9707734,0.005419788,0.01447292,0.005728987],"study_design_scores_gemma":[0.001549575,0.0007636689,0.002141715,0.0001058795,0.0002452696,0.0002454823,0.0005190001,0.0003677685,0.7988718,0.002431916,0.1909916,0.001766332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629745,0.0006308362,0.002025232,0.0003818772,0.000389783,0.0005728978,0.00006969635,0.0006739103,0.03228125],"genre_scores_gemma":[0.9667253,0.0004676693,0.02820846,0.002203993,0.0003756507,0.00003378173,0.0001121625,0.0002914183,0.001581546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1765186,"threshold_uncertainty_score":0.9992971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133989025679938,"score_gpt":0.2513813790520937,"score_spread":0.2400414887952943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}