{"id":"W2178127499","doi":"10.1002/anie.201509345","title":"Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Institutes of Health; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Polyketide synthase; Gene cluster; Polyketide; Plasmodium falciparum; Heterologous expression; Biochemistry; Biosynthesis; Biology; Gene; Enzyme; Heterologous; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126847,0.0003192249,0.0001704749,0.0001251347,0.00009900053,0.0002800996,0.0001593662,0.0001647078,0.0006885589],"category_scores_gemma":[0.0001465123,0.0001408554,0.0002079287,0.0001816992,0.000141376,0.0001545273,0.0001310994,0.0004637044,0.0003548082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351672,"about_ca_system_score_gemma":0.0002440943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009144978,"about_ca_topic_score_gemma":0.0009654118,"domain_scores_codex":[0.9999293,0.00001209983,0.000007335398,0.0000142441,0.00002225703,0.00001463753],"domain_scores_gemma":[0.9999056,0.00001362837,0.00002141675,0.0000205933,0.00001174624,0.00002697337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009695733,0.00003691051,0.00009572024,0.00002196406,0.000003822716,0.00002873886,0.00001516885,0.0006388327,0.9972791,0.000171068,0.00002547932,0.001586175],"study_design_scores_gemma":[0.00001521159,0.0002357016,0.0007277468,0.000005376311,0.00001208132,0.00008690615,0.0000143695,0.001788684,0.9935328,0.00003572524,0.003540947,0.000004530603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909797,0.0005284241,0.005487429,0.00005595965,0.00002988473,0.00006880274,0.0006865915,0.00007650901,0.002086595],"genre_scores_gemma":[0.9894435,0.0005172924,0.007172266,0.00001717939,0.000004348248,0.0000218796,0.001129264,0.00003236119,0.001661978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009144978,"threshold_uncertainty_score":0.002551556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318792826292671,"score_gpt":0.2834071892246174,"score_spread":0.2402192609616907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}