{"id":"W2178156564","doi":"10.1089/108497802320970271","title":"Fusion of the C <sub>H</sub> 1 Domain of IgG <sub>1</sub> to Epidermal Growth Factor (EGF) Prolongs its Retention in the Blood but Does Not Increase Tumor Uptake","year":2002,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Molecular biology; Fusion protein; Epidermal growth factor; Linker; Chemistry; Western blot; Transfection; Epidermal growth factor receptor; Biology; Receptor; Recombinant DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006611416,0.0002814724,0.0005382593,0.0001639879,0.000160786,0.00002192543,0.0002870202,0.0001356079,0.0001826548],"category_scores_gemma":[0.0001159244,0.0001403323,0.0002158927,0.0004835809,0.0004186423,0.0000966628,0.00007715499,0.0004542512,0.000005928626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004713107,"about_ca_system_score_gemma":0.00008137285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001275597,"about_ca_topic_score_gemma":0.00003085452,"domain_scores_codex":[0.9974482,0.0003844094,0.000604788,0.0004092154,0.0006573684,0.0004960037],"domain_scores_gemma":[0.9988319,0.0002774897,0.0001708962,0.0002893606,0.0001549241,0.0002754408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001985496,0.0003908814,0.009098072,0.0005226545,0.0001402821,0.00005542359,0.001045616,0.000001503664,0.968258,0.0002563633,0.0001541975,0.01809155],"study_design_scores_gemma":[0.002657517,0.0003756123,0.06345306,0.0003160824,0.00009559062,0.00008886678,0.00007965802,0.0002219569,0.9309184,0.00006620062,0.001554242,0.0001728304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781117,0.006836013,0.000006122538,0.01302082,0.0001607828,0.001411253,0.0003481612,0.00001564552,0.00008949243],"genre_scores_gemma":[0.9778408,0.01750332,0.00004923208,0.004051038,0.0003112072,0.0001056375,0.000005047081,0.00002734725,0.0001064119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05435499,"threshold_uncertainty_score":0.5722584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04591234637436718,"score_gpt":0.3258154123211904,"score_spread":0.2799030659468232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}