{"id":"W2178156564","doi":"10.1089/108497802320970271","title":"Fusion of the C <sub>H</sub> 1 Domain of IgG <sub>1</sub> to Epidermal Growth Factor (EGF) Prolongs its Retention in the Blood but Does Not Increase Tumor Uptake","year":2002,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Molecular biology; Fusion protein; Epidermal growth factor; Linker; Chemistry; Western blot; Transfection; Epidermal growth factor receptor; Biology; Receptor; Recombinant DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083255,0.0003294739,0.0002836959,0.000158235,0.0001010935,0.0002307919,0.0002268116,0.0002899675,0.001756421],"category_scores_gemma":[0.00009664314,0.00008717918,0.0002839115,0.0001319029,0.0002206358,0.0001503839,0.0001340022,0.0004694148,0.0008088624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007085122,"about_ca_system_score_gemma":0.0002269538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366865,"about_ca_topic_score_gemma":0.001094015,"domain_scores_codex":[0.9999189,0.000006804519,0.000003571502,0.00001285317,0.00001904179,0.0000386996],"domain_scores_gemma":[0.9999211,0.00001846686,0.000024129,0.000009472023,0.000007512936,0.00001934267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009455049,0.00001736624,0.0001411723,0.00002501211,0.00000550003,0.00003528541,0.000005622974,0.00005230016,0.9984058,0.00007011682,0.00008032045,0.001067124],"study_design_scores_gemma":[0.0000134145,0.0001583893,0.002115951,0.000003350764,0.00001389553,0.0002791037,0.00000769874,0.0003619732,0.9928704,0.00003390894,0.004138733,0.000003252849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892522,0.001835653,0.005769637,0.0001688566,0.00005642622,0.00003936954,0.0004551701,0.0002159514,0.002206739],"genre_scores_gemma":[0.9884229,0.0009239989,0.003625555,0.0001245604,0.00002315868,0.0000273962,0.001583092,0.00004572075,0.005223501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756421,"threshold_uncertainty_score":0.005875826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04591234637436718,"score_gpt":0.3258154123211904,"score_spread":0.2799030659468232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}