{"id":"W2178248816","doi":"10.7554/elife.07938","title":"Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Natural Science Foundation of China; University of Alabama at Birmingham","keywords":"RNA splicing; RNA-binding protein; Biology; Ubiquitin ligase; Cell biology; Methylation; Alternative splicing; RUNX1; RNA; Downregulation and upregulation; Transcription factor; Molecular biology; Ubiquitin; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001364119,0.0002665917,0.0002265838,0.000149787,0.0001721474,0.0002720456,0.0002392556,0.000219499,0.001049038],"category_scores_gemma":[0.0001083328,0.00018366,0.0002817755,0.0001234991,0.0002656978,0.0002407354,0.0003157215,0.0003119085,0.0004682665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003910355,"about_ca_system_score_gemma":0.0001515894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004395862,"about_ca_topic_score_gemma":0.0008986498,"domain_scores_codex":[0.9998606,0.00001907681,0.00001045688,0.00004786388,0.00002650726,0.00003546082],"domain_scores_gemma":[0.9999373,0.000007962403,0.00002630056,0.000008262796,0.000005720917,0.00001436107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006944585,0.000005389657,0.0005176837,0.00001678821,0.000004009541,0.00003648239,0.00001062956,0.00004900579,0.9979522,0.0001613676,0.0000185118,0.001158417],"study_design_scores_gemma":[0.000008256725,0.00005077741,0.006188179,0.000002654567,0.00000983889,0.0001521849,0.00001061641,0.0007987146,0.9915715,0.00005946277,0.001145215,0.000002547942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918925,0.002585969,0.003852042,0.00008539734,0.00001663768,0.0000107351,0.0001353431,0.00006390599,0.001357594],"genre_scores_gemma":[0.9963837,0.000606045,0.001444913,0.00002706534,0.000004255124,0.000009028738,0.0001741023,0.00001131855,0.001339604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049038,"threshold_uncertainty_score":0.003509402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228464275679916,"score_gpt":0.3044367292453472,"score_spread":0.2815903016773556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}