{"id":"W2178248816","doi":"10.7554/elife.07938","title":"Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Natural Science Foundation of China; University of Alabama at Birmingham","keywords":"RNA splicing; RNA-binding protein; Biology; Ubiquitin ligase; Cell biology; Methylation; Alternative splicing; RUNX1; RNA; Downregulation and upregulation; Transcription factor; Molecular biology; Ubiquitin; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003861155,0.0001298721,0.0001399845,0.00005815448,0.00006630059,0.00004387146,0.00005854962,0.000215475,0.000008173535],"category_scores_gemma":[0.0002936022,0.0001319303,0.00003730462,0.00009868357,0.0000451817,0.00001062569,0.00004144014,0.00008728718,0.00001857961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005220619,"about_ca_system_score_gemma":0.000068571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005513155,"about_ca_topic_score_gemma":0.00003130078,"domain_scores_codex":[0.9990285,0.00006673481,0.0002212565,0.0002905832,0.0002266111,0.0001663112],"domain_scores_gemma":[0.9993467,0.00003307124,0.0001314031,0.0002034589,0.0001617773,0.0001236248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002654252,0.00002379794,0.03447343,0.00001291172,0.00008872299,9.11181e-7,0.0001348965,0.00477588,0.9421127,0.00004207931,0.0007277842,0.0173414],"study_design_scores_gemma":[0.002599122,0.000529804,0.2235621,0.00002707952,0.00004602595,0.000004201134,0.00002559811,0.002576601,0.7559318,0.00009375226,0.01430648,0.0002974183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954215,0.0005673612,0.002493779,0.0002056352,0.0001589907,0.0002654355,0.00001982184,0.00003112932,0.0008363412],"genre_scores_gemma":[0.9981421,0.00003711347,0.0001579874,0.0001342317,0.0007294567,0.0000132749,0.0004626448,0.00002235879,0.0003008829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1890887,"threshold_uncertainty_score":0.5379961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0228464275679916,"score_gpt":0.3044367292453472,"score_spread":0.2815903016773556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}