{"id":"W2178343817","doi":"10.1016/s0960-894x(02)00765-5","title":"Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Proteases; Cysteine; Cathepsin; Stereochemistry; Amino acid; Cathepsin L; Enzyme inhibitor; Cysteine Proteinase Inhibitors; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969272,0.0003834994,0.0006629583,0.0002814023,0.0001931573,0.0003853157,0.0007246255,0.0003690501,0.001873103],"category_scores_gemma":[0.0001802351,0.0002816458,0.0002312272,0.0002834496,0.0001988251,0.0002157757,0.0001889889,0.0006361096,0.0007675955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004671196,"about_ca_system_score_gemma":0.0004120244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005385875,"about_ca_topic_score_gemma":0.0009669689,"domain_scores_codex":[0.9998496,0.00002839912,0.00001478555,0.00002056152,0.00003378473,0.00005291501],"domain_scores_gemma":[0.9999291,0.000006589129,0.00001522085,0.000006001387,0.00001320197,0.00002981337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006046348,0.0002064071,0.0001505745,0.0002599125,0.00002758151,0.0003397079,0.00008167588,0.002207444,0.9771839,0.002119117,0.0004219743,0.01639715],"study_design_scores_gemma":[0.0002825492,0.001606339,0.0007171209,0.00002002175,0.00004979353,0.0003539431,0.00002355011,0.002575482,0.9809817,0.0002352465,0.01312243,0.00003182783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593388,0.008495424,0.01616894,0.0004530545,0.0004006904,0.0004845872,0.0006849435,0.0003733576,0.01360011],"genre_scores_gemma":[0.9712737,0.004809388,0.01522277,0.0001448987,0.00005621299,0.0002069372,0.0006985457,0.00005198961,0.007535622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873103,"threshold_uncertainty_score":0.006266177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424839368685035,"score_gpt":0.2060721349761807,"score_spread":0.1918237412893304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}