{"id":"W2178416825","doi":"10.1021/acsami.5b07929","title":"A Delicate Balance When Substituting a Small Hydrophobe onto Low Molecular Weight Polyethylenimine to Improve Its Nucleic Acid Delivery Efficiency","year":2015,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Alberta Innovates - Technology Futures","keywords":"Polyethylenimine; Cationic polymerization; Nucleic acid; Biophysics; Hydrophobic effect; Gene silencing; Hydrophobe; Surface charge; Cytotoxicity; Combinatorial chemistry; Chemistry; Materials science; Nanotechnology; Biochemistry; Transfection; Organic chemistry; Biology; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430472,0.0003195574,0.0002091954,0.00007519635,0.0001241197,0.0002518383,0.0002054997,0.0002819236,0.0009021246],"category_scores_gemma":[0.0002604416,0.0001482818,0.0001408825,0.0000849292,0.0002290123,0.0004824983,0.0001801341,0.0003434833,0.0002130843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622824,"about_ca_system_score_gemma":0.0002483672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003524646,"about_ca_topic_score_gemma":0.0006230946,"domain_scores_codex":[0.9999396,0.00000795063,0.000003689228,0.00001428807,0.00001646652,0.00001808324],"domain_scores_gemma":[0.9999453,0.00001804136,0.0000147107,0.000005247143,0.000008393535,0.000008409832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005812648,0.00002938058,0.0003460494,0.0001210298,0.00001213589,0.0001388796,0.00003565882,0.002912021,0.9918116,0.000973752,0.00006854541,0.00349275],"study_design_scores_gemma":[0.00003887243,0.0003973659,0.00221907,0.00001995636,0.00005429012,0.0001710062,0.00008170955,0.04003226,0.9515955,0.0007516931,0.004612447,0.00002577068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844961,0.00095563,0.01174082,0.0001928956,0.0000483062,0.0000636952,0.00005497729,0.00009840706,0.002349151],"genre_scores_gemma":[0.992358,0.000647256,0.006125306,0.00005316923,0.000007879001,0.00003900416,0.00003853424,0.00002126472,0.0007095012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009021246,"threshold_uncertainty_score":0.003017902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327356707941611,"score_gpt":0.2256832227040257,"score_spread":0.2124096556246096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}