{"id":"W2178422273","doi":"10.1016/s0960-894x(02)00732-1","title":"Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Abbott Laboratories","keywords":"Chemistry; Neuraminidase inhibitor; Neuraminidase; Stereochemistry; Inhibitory postsynaptic potential; Structure–activity relationship; Enzyme inhibitor; Chemical synthesis; Amino acid; Biochemistry; In vitro; Enzyme; Neuroscience; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002834411,0.0006100409,0.0007843409,0.00005584153,0.0001545879,0.00004447667,0.0004767287,0.0003929177,0.002360413],"category_scores_gemma":[0.0003346752,0.0005931706,0.0001963687,0.0002655157,0.000778491,0.0001537552,0.0001308386,0.0005660089,0.00001283066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686533,"about_ca_system_score_gemma":0.00005684776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005256675,"about_ca_topic_score_gemma":0.000001096119,"domain_scores_codex":[0.9972836,0.00004474155,0.00053121,0.0008636572,0.0006472667,0.0006295064],"domain_scores_gemma":[0.9975246,0.0007950622,0.0004154601,0.0008274974,0.00003951596,0.0003979193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100399,0.0002640861,0.0005601317,0.0008860335,0.0001534832,0.0001382364,0.000276727,0.000002107282,0.9955637,5.457212e-7,0.0008564532,0.001188484],"study_design_scores_gemma":[0.0007500995,0.00001332343,0.0002623813,0.0003555119,0.0002771192,0.0003088128,0.0002264848,0.0005007302,0.9962984,0.000004379538,0.0004591656,0.0005435974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953496,0.001197561,0.0001634571,0.00177903,0.00007902915,0.00009726948,0.00007401805,0.0001370381,0.001123029],"genre_scores_gemma":[0.9986436,0.0003036617,0.00011138,0.000229017,0.0004158043,0.00003632827,0.00001766155,0.00007033984,0.0001722432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003293996,"threshold_uncertainty_score":0.999652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04355357369555066,"score_gpt":0.2121786598470778,"score_spread":0.1686250861515271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}