{"id":"W2178423748","doi":"10.1016/j.bmcl.2008.03.057","title":"Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bristol-Myers Squibb (Canada)","funders":"","keywords":"Chemistry; In vivo; Isopropyl; Potency; Tyrosine kinase; Stereochemistry; Chemical synthesis; Pharmacokinetics; Structure–activity relationship; In vitro; Selectivity; Receptor tyrosine kinase; Kinase; Tyrosine-kinase inhibitor; Enzyme inhibitor; Pharmacology; Receptor; Biochemistry; Medicinal chemistry; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006996179,0.0006806544,0.001060695,0.0001267191,0.0001833178,0.00002279433,0.0005266473,0.0005678137,0.00007105105],"category_scores_gemma":[0.0006325501,0.0006019466,0.0002924378,0.0003994835,0.001323404,0.00005090945,0.0003658776,0.0004922192,0.000004519732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733341,"about_ca_system_score_gemma":0.0003096887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008713033,"about_ca_topic_score_gemma":0.00003143861,"domain_scores_codex":[0.9960217,0.0001830571,0.00107261,0.001322472,0.0006248792,0.000775299],"domain_scores_gemma":[0.9979734,0.0001695776,0.0004990457,0.0008096609,0.0001965977,0.0003516569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008964111,0.0003130003,0.006199882,0.0002234066,0.0003803241,0.000105868,0.000512059,0.00001037516,0.9871694,0.00000191888,0.003120746,0.001066606],"study_design_scores_gemma":[0.002583545,0.0006091728,0.00930073,0.0001972503,0.0001690692,0.0001878045,0.001123307,0.00002049205,0.982183,0.00001294976,0.002960751,0.0006519642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861452,0.01047579,0.0001083287,0.002197576,0.0004155725,0.0004009708,0.0001315815,0.00003336481,0.00009159114],"genre_scores_gemma":[0.9905313,0.005304941,0.0003631362,0.001488561,0.001785852,0.00006882143,0.0001190555,0.00009213166,0.0002461994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005170847,"threshold_uncertainty_score":0.9996432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03409842707840115,"score_gpt":0.3030423123951475,"score_spread":0.2689438853167463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}