{"id":"W2178428837","doi":"10.1016/j.molonc.2015.11.009","title":"ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor‐positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines","year":2015,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Frontier Research Institute for Interdisciplinary Sciences, Tohoku University; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Cancer research; Wnt signaling pathway; Progenitor cell; Estrogen receptor; Cancer stem cell; Stem cell; Downregulation and upregulation; Cancer cell; Signal transduction; Breast cancer; Cancer; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005297083,0.000478828,0.0007469199,0.0001548348,0.00007020003,0.00003295612,0.0002954966,0.000551566,0.0002008569],"category_scores_gemma":[0.00004181791,0.0003866826,0.0001220334,0.0004746769,0.0004472583,0.0001365788,0.0002188677,0.000746261,0.00002346295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001585193,"about_ca_system_score_gemma":0.001546779,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02678914,"about_ca_topic_score_gemma":0.01539017,"domain_scores_codex":[0.997,0.0004108396,0.0005983099,0.0008100183,0.0004383142,0.0007425294],"domain_scores_gemma":[0.9984842,0.00009703895,0.0002794939,0.0004856429,0.0003174239,0.0003361969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001755266,0.0007206679,0.007342439,0.00008937944,0.0001048594,0.0006748549,0.002914294,0.0006515834,0.9658849,0.00004855572,0.0004142234,0.01939898],"study_design_scores_gemma":[0.01155367,0.001301865,0.04289026,0.0007630904,0.0002883223,0.001337204,0.00380889,0.000911112,0.9297361,0.00005211232,0.006401418,0.0009559022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757225,0.01327062,0.00004601111,0.007665989,0.0005077271,0.0009994487,0.0004068587,0.0000489192,0.001331943],"genre_scores_gemma":[0.9948434,0.001129752,0.0003390969,0.002468131,0.0004040056,0.0003240214,0.00003920569,0.0000992275,0.0003532023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03614873,"threshold_uncertainty_score":0.9998585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01602319409112985,"score_gpt":0.2769686633884612,"score_spread":0.2609454692973313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}