{"id":"W2178723052","doi":"10.2967/jnumed.115.162743","title":"Human Kinetic Modeling of the 5HT6 PET Radioligand <sup>11</sup>C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"GlaxoSmithKline","keywords":"Ketanserin; Radioligand; Binding potential; 5-HT2A receptor; Antagonist; Pharmacology; In vivo; Receptor; Chemistry; Receptor antagonist; Striatum; 5-HT receptor; Serotonin; Internal medicine; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003948765,0.0004567311,0.0002654813,0.000192113,0.0001323833,0.0005857158,0.000439809,0.0005450168,0.001867685],"category_scores_gemma":[0.0006727916,0.0002106833,0.0003974182,0.0002036505,0.0002009934,0.0001643358,0.0001615857,0.0003177047,0.0006927513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008058103,"about_ca_system_score_gemma":0.0006484524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01452379,"about_ca_topic_score_gemma":0.008366884,"domain_scores_codex":[0.9998969,0.0000361543,0.000004274637,0.00003078475,0.00002087698,0.0000110602],"domain_scores_gemma":[0.9998466,0.00008904665,0.00002734575,0.00001029452,0.00001937219,0.000007353975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001912215,0.0001151068,0.008290077,0.0002882204,0.0002130592,0.000443648,0.0001920749,0.8416389,0.09232541,0.003457109,0.00175008,0.04937409],"study_design_scores_gemma":[0.00003217595,0.0003341008,0.004661979,0.00001454485,0.00007450126,0.0004293098,0.00002803951,0.9633241,0.02699303,0.0006713093,0.00340949,0.00002740367],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5975674,0.002890814,0.3859779,0.0004732469,0.00003598786,0.0001541237,0.00188222,0.001169485,0.009848894],"genre_scores_gemma":[0.9702138,0.0007726094,0.02373041,0.00009621117,0.000009496797,0.0001269813,0.0008461836,0.000145896,0.00405845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01452379,"threshold_uncertainty_score":0.02887845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07918891832429431,"score_gpt":0.3498858716492091,"score_spread":0.2706969533249148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}