{"id":"W2178878751","doi":"10.1101/gad.270611.115","title":"Structural basis for substrate recognition by the human N-terminal methyltransferase 1","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Biological and Environmental Research; Ministero dello Sviluppo Economico; Novartis Pharma; Canada Foundation for Innovation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Ontario Ministry of Economic Development and Innovation; Virginia Commonwealth University; University of Chicago; European Federation of Pharmaceutical Industries and Associations; AbbVie; Innovative Medicines Initiative; Wellcome; Pfizer; Boehringer Ingelheim; Argonne National Laboratory; U.S. Department of Energy","keywords":"Methylation; Biology; Methyltransferase; DNA methylation; Cell biology; Biochemistry; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232221,0.0001413147,0.00008970012,0.00002294625,0.0001682796,0.00002934076,0.0001201455,0.0001033366,0.00001753445],"category_scores_gemma":[0.0000137163,0.0001140126,0.00005238913,0.00005664929,0.00003846808,0.000004555925,0.00002445012,0.00004072482,0.000007376334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005880588,"about_ca_system_score_gemma":0.000183371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001729947,"about_ca_topic_score_gemma":0.0001218064,"domain_scores_codex":[0.9991459,0.00004054268,0.0002139131,0.0002612954,0.0001352538,0.0002030635],"domain_scores_gemma":[0.9995568,0.000007331574,0.00005648096,0.0001586235,0.0001438607,0.00007687169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001228831,0.00001659497,0.000433098,0.00001684622,0.0001119145,7.943373e-7,0.0003527442,0.0001554307,0.7959289,0.000007308452,0.005946658,0.1969068],"study_design_scores_gemma":[0.0006254955,0.00009819806,0.002433653,0.000008500046,0.00003276956,0.00002431553,0.0001062655,0.00003839281,0.9393327,0.000164506,0.05691895,0.0002162998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954445,0.001180376,0.002450518,0.000185551,0.00024326,0.0003519579,0.00004173419,0.00001275007,0.00008934052],"genre_scores_gemma":[0.9947386,0.00004478385,0.002867604,0.0001113403,0.0002368681,0.0001547572,0.001378158,0.00002216445,0.0004457562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1966905,"threshold_uncertainty_score":0.4649301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672289257254791,"score_gpt":0.2793434128414744,"score_spread":0.2426205202689265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}