{"id":"W2178878751","doi":"10.1101/gad.270611.115","title":"Structural basis for substrate recognition by the human N-terminal methyltransferase 1","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Biological and Environmental Research; Ministero dello Sviluppo Economico; Novartis Pharma; Canada Foundation for Innovation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Ontario Ministry of Economic Development and Innovation; Virginia Commonwealth University; University of Chicago; European Federation of Pharmaceutical Industries and Associations; AbbVie; Innovative Medicines Initiative; Wellcome; Pfizer; Boehringer Ingelheim; Argonne National Laboratory; U.S. Department of Energy","keywords":"Methylation; Biology; Methyltransferase; DNA methylation; Cell biology; Biochemistry; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008926792,0.0003222512,0.0002919643,0.00008342425,0.0002436962,0.0002996503,0.0003876849,0.0004550237,0.001758526],"category_scores_gemma":[0.0002549461,0.0001430111,0.0002067437,0.00007865136,0.0001769772,0.0001749254,0.0001938406,0.0003720008,0.0007902465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503207,"about_ca_system_score_gemma":0.0002329543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005609572,"about_ca_topic_score_gemma":0.0005164933,"domain_scores_codex":[0.9999108,0.00001540241,0.000005400298,0.00002707524,0.0000246767,0.00001669373],"domain_scores_gemma":[0.9999226,0.00001248438,0.00001960046,0.000006712621,0.0000121488,0.00002649005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004042463,0.00007064399,0.003054602,0.0001862535,0.00002560958,0.001093928,0.0001027578,0.002585672,0.9807387,0.00336634,0.0006343448,0.007736872],"study_design_scores_gemma":[0.0001292962,0.0009828386,0.02395442,0.00004745953,0.00006000745,0.005155175,0.0002167211,0.03659353,0.9061971,0.00396737,0.02263188,0.00006429503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776942,0.004229289,0.01142033,0.0004503521,0.00007796521,0.00004119648,0.0002193661,0.0002412088,0.005626136],"genre_scores_gemma":[0.9949786,0.0006449363,0.002494207,0.00009071701,0.00001551223,0.00001107969,0.0003687374,0.00001035883,0.001385892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001758526,"threshold_uncertainty_score":0.0058828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672289257254791,"score_gpt":0.2793434128414744,"score_spread":0.2426205202689265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}