{"id":"W2178925859","doi":"10.1093/jac/dkv340","title":"Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins","year":2015,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Faculté de pharmacie, Université de Montréal; National Institutes of Health; University of Sydney","keywords":"Oligopeptide; Transporter; Symporter; Polymyxin; Chemistry; Biology; Bacteria; Biochemistry; Gene; Peptide; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738605,0.0003175054,0.0002376002,0.00007860757,0.0001267201,0.000293529,0.0001650807,0.0004596519,0.0009887156],"category_scores_gemma":[0.0001998539,0.0001109465,0.0003117069,0.0001420442,0.000152047,0.0002163468,0.0001558113,0.0003665092,0.000407528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014732,"about_ca_system_score_gemma":0.0002056018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008539309,"about_ca_topic_score_gemma":0.0006573995,"domain_scores_codex":[0.9998196,0.00003813665,0.00001427316,0.0000451699,0.00004098346,0.0000418933],"domain_scores_gemma":[0.9999263,0.00001315649,0.00002200148,0.000006885975,0.00001420593,0.00001733589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001751675,0.0000191104,0.0005516898,0.00006759586,0.000009947813,0.00007606018,0.00001191013,0.00009259688,0.9977093,0.00005044748,0.0001047473,0.001131406],"study_design_scores_gemma":[0.00003654963,0.0002699081,0.008689482,0.00001241564,0.00002402407,0.0008269643,0.00002714196,0.003335184,0.9826986,0.00003539209,0.00403665,0.000007719591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872176,0.00623183,0.003983222,0.0003188087,0.00003829853,0.00003344547,0.000537633,0.00008819989,0.001551035],"genre_scores_gemma":[0.9937068,0.001947423,0.001851375,0.0001027126,0.00001585541,0.00002417919,0.0006738741,0.00001312162,0.001664683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009887156,"threshold_uncertainty_score":0.003307581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928247136928653,"score_gpt":0.2591240598335744,"score_spread":0.2398415884642879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}