{"id":"W2178938680","doi":"10.1038/srep15662","title":"Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"AO Foundation","keywords":"Intervertebral disc; Degenerative disc disease; Microarray analysis techniques; CTGF; Gene expression profiling; Medicine; Microarray; Biology; Gene expression; Cancer research; Bioinformatics; Gene; Cell biology; Pathology; Genetics; Growth factor; Anatomy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516735,0.0001689903,0.0003275675,0.0006949535,0.0002741508,0.0002846981,0.00007155207,0.000254044,0.001100773],"category_scores_gemma":[0.0002189075,0.0001322741,0.0003083704,0.0006770339,0.0001544024,0.0001037284,0.0001293938,0.0002472913,0.0003413779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002001926,"about_ca_system_score_gemma":0.0001944162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113448,"about_ca_topic_score_gemma":0.001730709,"domain_scores_codex":[0.9998648,0.00001353264,0.00001198278,0.00002908495,0.00004873267,0.00003178077],"domain_scores_gemma":[0.9998966,0.0000323208,0.00002600076,0.000006803823,0.00002486424,0.00001331197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004374658,0.00002189799,0.005691583,0.00008576492,0.00001347679,0.0001044037,0.0000760795,0.00005389816,0.9907776,0.00002451261,0.00008308825,0.002630125],"study_design_scores_gemma":[0.00003957649,0.0009608227,0.6676054,0.00004238073,0.0001499842,0.001668946,0.0006470011,0.002003232,0.3230975,0.0001894833,0.00356804,0.0000276064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934809,0.002041264,0.001268544,0.00008547433,0.00001908435,0.00002307236,0.002462852,0.00003244168,0.0005863754],"genre_scores_gemma":[0.9860213,0.001928047,0.004920862,0.0001628293,0.00002109489,0.00009074543,0.004590527,0.00001146428,0.002253131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113448,"threshold_uncertainty_score":0.003682494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04508049125317128,"score_gpt":0.3178676071142405,"score_spread":0.2727871158610692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}