{"id":"W2178938680","doi":"10.1038/srep15662","title":"Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"AO Foundation","keywords":"Intervertebral disc; Degenerative disc disease; Microarray analysis techniques; CTGF; Gene expression profiling; Medicine; Microarray; Biology; Gene expression; Cancer research; Bioinformatics; Gene; Cell biology; Pathology; Genetics; Growth factor; Anatomy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008491187,0.0001507427,0.0002762789,0.0002707578,0.0001215002,0.0001341754,0.00006033616,0.00008621182,0.00003924956],"category_scores_gemma":[0.0002209761,0.0001226578,0.00005687349,0.0002151114,0.0002212531,0.0002355126,0.0001402835,0.0001458167,0.000008322714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005860512,"about_ca_system_score_gemma":0.00009214394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004684731,"about_ca_topic_score_gemma":0.0000448742,"domain_scores_codex":[0.9981925,0.00006614878,0.0005181899,0.0006652759,0.0002949913,0.000262823],"domain_scores_gemma":[0.9991119,0.000003392232,0.0001666074,0.0003520518,0.0001992144,0.0001668714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001993673,0.00006286755,0.00792855,0.00003636442,0.000007066548,0.001270965,0.001256795,0.00004383079,0.9856353,0.0000223694,0.00352367,0.0001922914],"study_design_scores_gemma":[0.0003943269,0.0002746872,0.002935309,0.0002599513,0.00001700572,0.0005692464,0.0009510391,0.0004351415,0.9920585,0.00190724,0.00006567484,0.0001318522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955088,0.0009622228,0.0006835214,0.00008923317,0.001421488,0.0003173319,0.000001392588,0.00004438992,0.0009716182],"genre_scores_gemma":[0.9937591,0.000002714031,0.002981759,0.0000445945,0.00007580689,0.00002833297,0.00009537876,0.00001571006,0.002996624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006423233,"threshold_uncertainty_score":0.5001839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04508049125317128,"score_gpt":0.3178676071142405,"score_spread":0.2727871158610692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}