{"id":"W2179075918","doi":"10.1074/jbc.m115.674929","title":"Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Biological and Environmental Research; National Center for Research Resources; Western Economic Diversification Canada; Ohio State University; National Institutes of Health; University of Toronto; National Institute of Allergy and Infectious Diseases; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Saskatchewan; Canadian Institutes of Health Research; U.S. Department of Energy","keywords":"Pseudomonas aeruginosa; Biosynthesis; Biofilm; Glycoside hydrolase; Polysaccharide; PSL; Microbiology; Chemistry; Hydrolase; Glycoside; Biochemistry; Biology; Stereochemistry; Bacteria; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00043147,0.0001653354,0.0002971951,0.0000202977,0.00007143808,0.00003383984,0.000182385,0.0003151511,0.000008658832],"category_scores_gemma":[0.001244728,0.0001037316,0.000172103,0.00006157342,0.0001387072,0.00002345903,0.00009667182,0.0001179583,4.206205e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000201468,"about_ca_system_score_gemma":0.00005498487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.157678e-7,"about_ca_topic_score_gemma":3.139498e-7,"domain_scores_codex":[0.9989343,0.00007112772,0.0004651369,0.0001812396,0.000143741,0.000204492],"domain_scores_gemma":[0.9987322,0.0000665531,0.0005806257,0.0001646761,0.0003059078,0.0001500356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003054585,0.00004780151,0.001422425,0.0000641815,0.00002528481,0.00000215313,0.00001670761,6.39506e-7,0.9975883,0.000007202647,0.0000996642,0.0004202084],"study_design_scores_gemma":[0.0004817471,0.0001789191,0.005462301,0.00009969659,0.00003917887,0.0002256387,0.00008705574,0.00002588775,0.992368,0.00006705937,0.0008287452,0.0001357121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976546,0.0003361207,0.0002944887,0.001226955,0.000163867,0.0001221534,0.0001719992,0.000004363152,0.00002548825],"genre_scores_gemma":[0.9986311,0.0001350745,0.0005666261,0.000219662,0.0003813591,0.000002836333,0.00002320149,0.000009941655,0.00003022408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005220215,"threshold_uncertainty_score":0.4230053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05123927469421111,"score_gpt":0.2668172305299403,"score_spread":0.2155779558357292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}