{"id":"W2179116990","doi":"10.1021/jo051105t","title":"High Yielding Synthesis of 3<i>a</i>-Hydroxypyrrolo[2,3-<i>b</i>]indoline Dipeptide Methyl Esters:  Synthons for Expedient Introduction of the Hydroxypyrroloindoline Moiety into Larger Peptide-Based Natural Products and for the Creation of Tryptathionine Bridges","year":2005,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Dipeptide; Chemistry; Synthon; Indoline; Moiety; Stereochemistry; Peptide; Peptide synthesis; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001180151,0.000197095,0.0004469209,0.00002760874,0.0001250764,0.00001021147,0.0004080335,0.000121983,0.00001940094],"category_scores_gemma":[0.002808569,0.0001060722,0.0003303196,0.0001741697,0.000275054,0.00001414669,0.0000939009,0.0001731316,5.224359e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003648336,"about_ca_system_score_gemma":0.0001011989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000144534,"about_ca_topic_score_gemma":0.00001228212,"domain_scores_codex":[0.9985085,0.00007208712,0.000772621,0.0002105917,0.0002565855,0.0001796459],"domain_scores_gemma":[0.9973056,0.0005914331,0.001127949,0.0004481946,0.0004852158,0.00004165227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005558186,0.0001472624,0.000153052,0.0002460294,0.0002688165,5.118394e-8,0.0001311616,0.0009727195,0.9954357,0.000002233684,0.0004776664,0.001609472],"study_design_scores_gemma":[0.0006763609,0.0000934667,0.0002575645,0.00009256606,0.0007446412,0.00002550941,0.0002855118,0.0008439202,0.9959826,0.00002273546,0.0008672667,0.0001078224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862279,0.002173363,0.003027546,0.008211144,0.00007798005,0.0002400525,0.0000355442,0.000002760657,0.000003693557],"genre_scores_gemma":[0.9958416,0.000371858,0.002444543,0.0000619945,0.001140739,0.00001386442,0.00001562781,0.00002449555,0.00008522591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009613737,"threshold_uncertainty_score":0.4325497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005689236766426179,"score_gpt":0.2286386645925071,"score_spread":0.2229494278260809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}