{"id":"W2179116990","doi":"10.1021/jo051105t","title":"High Yielding Synthesis of 3<i>a</i>-Hydroxypyrrolo[2,3-<i>b</i>]indoline Dipeptide Methyl Esters:  Synthons for Expedient Introduction of the Hydroxypyrroloindoline Moiety into Larger Peptide-Based Natural Products and for the Creation of Tryptathionine Bridges","year":2005,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Dipeptide; Chemistry; Synthon; Indoline; Moiety; Stereochemistry; Peptide; Peptide synthesis; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387311,0.0003222066,0.0001699038,0.0001405716,0.00009217347,0.0001428517,0.0002426265,0.000196815,0.0009032527],"category_scores_gemma":[0.0001409171,0.0001411662,0.0001647723,0.0001226316,0.00009354488,0.0002454259,0.0001985538,0.000339101,0.0007273867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507671,"about_ca_system_score_gemma":0.0002066885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319408,"about_ca_topic_score_gemma":0.0003387557,"domain_scores_codex":[0.999926,0.00001029477,0.000009512307,0.00001704769,0.00002230015,0.0000148452],"domain_scores_gemma":[0.9999107,0.0000119144,0.00002968221,0.00001101349,0.00001688621,0.00001977276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002525266,0.000006757231,0.0000386739,0.00003528607,0.000002802722,0.00005411931,0.000016246,0.00009346824,0.9969153,0.0001314932,0.00002206523,0.002658423],"study_design_scores_gemma":[0.000008081217,0.0001215436,0.0003198585,0.000002679265,0.000005918973,0.0001841549,0.000007776191,0.0002652759,0.9964856,0.00005284744,0.002541509,0.000004751187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.92377,0.002190668,0.06672364,0.000109726,0.00004741447,0.0001823555,0.0008580058,0.0003164812,0.005801816],"genre_scores_gemma":[0.9402754,0.001917775,0.05295456,0.00004101425,0.00001406106,0.0001146731,0.0008984841,0.00008405888,0.003699986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009032527,"threshold_uncertainty_score":0.003021657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005689236766426179,"score_gpt":0.2286386645925071,"score_spread":0.2229494278260809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}