{"id":"W2179182997","doi":"10.4049/jimmunol.1402787","title":"Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide–MHC Class II Multimers","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"T-cell receptor; Peptide; CD8; MHC restriction; Major histocompatibility complex; T cell; MHC class II; Biology; Antigen; Chemistry; Molecular biology; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002318829,0.0003697944,0.000182266,0.0001388934,0.00007766879,0.0002476108,0.000168812,0.0003554779,0.0007320725],"category_scores_gemma":[0.0001610639,0.0001106535,0.00010766,0.00009639942,0.0001436147,0.0002009459,0.0001855043,0.0004769419,0.0002243924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001523153,"about_ca_system_score_gemma":0.00008243896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008930956,"about_ca_topic_score_gemma":0.0001597193,"domain_scores_codex":[0.9998037,0.00005276489,0.00001066355,0.00005369936,0.00003918443,0.00003996879],"domain_scores_gemma":[0.9999117,0.0000346382,0.00001826388,0.00001136949,0.000009237986,0.00001474852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001438545,0.000003968763,0.00002919212,0.000006762139,7.16553e-7,0.000005286421,0.000002373064,0.00002381687,0.999544,0.00001656865,0.000005206563,0.0003476982],"study_design_scores_gemma":[0.000003986909,0.0001055442,0.0004589192,0.000001244798,0.000004366087,0.0000518942,0.000003562436,0.0009297337,0.9981087,0.00001773097,0.0003128833,0.000001249405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781508,0.0006061322,0.02013921,0.00005228363,0.00002569068,0.00002953783,0.00009942481,0.000123308,0.0007736503],"genre_scores_gemma":[0.9777464,0.000324485,0.02068646,0.00006143856,0.00001685446,0.00004188328,0.0001049201,0.00001856632,0.0009990146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007320725,"threshold_uncertainty_score":0.002448976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02951659251796584,"score_gpt":0.2505562120288749,"score_spread":0.2210396195109091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}