{"id":"W2179211850","doi":"10.1159/000438544","title":"SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch","year":2015,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Ottawa Hospital Research Institute","keywords":"Vascular smooth muscle; Calponin; Cell biology; Activator (genetics); Transfection; Sirtuin 1; Chemistry; Resveratrol; Biology; Downregulation and upregulation; Endocrinology; Internal medicine; Actin; Biochemistry; Smooth muscle; Receptor; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370276,0.0003212399,0.0002189515,0.0001822703,0.0002292233,0.0002054262,0.000167011,0.0003024868,0.001588596],"category_scores_gemma":[0.0001068193,0.0001136631,0.0003872562,0.0001554093,0.000352086,0.000189735,0.0002458807,0.0003848726,0.0002314025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002767277,"about_ca_system_score_gemma":0.0002123092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000565447,"about_ca_topic_score_gemma":0.00110292,"domain_scores_codex":[0.999902,0.00001432257,0.000007103424,0.00002444847,0.00002000475,0.00003200059],"domain_scores_gemma":[0.9999117,0.000005828209,0.00003391409,0.000006997854,0.00001356785,0.00002790644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005699777,0.00007834385,0.001612845,0.0002233275,0.00002562726,0.00009959101,0.00004888239,0.0001290527,0.991829,0.0002946378,0.0002448403,0.00484384],"study_design_scores_gemma":[0.000165341,0.001676425,0.1192604,0.00007240947,0.0002359462,0.0005576204,0.0002581488,0.003013509,0.860404,0.0005880332,0.01372834,0.00003983157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810106,0.01124231,0.003554861,0.0004533839,0.0001713775,0.0000377183,0.0003188644,0.0001442033,0.003066738],"genre_scores_gemma":[0.9935679,0.003150902,0.0009124031,0.00009268164,0.00004827682,0.0000304495,0.000293313,0.00000871862,0.001895311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001588596,"threshold_uncertainty_score":0.00531435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089794924561012,"score_gpt":0.2284411023328015,"score_spread":0.2175431530871914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}