{"id":"W2179638825","doi":"10.1016/j.ccell.2015.10.005","title":"MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Structural Genomics Consortium; Toronto Western Hospital; Princess Margaret Cancer Centre; McGill University Health Centre; Ontario Institute for Cancer Research; University Health Network; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chromatin; Histone; Biology; Cell biology; Cancer; Histone H3; Cancer research; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683203,0.0002249507,0.0001579424,0.0003131259,0.0003111562,0.0008257055,0.0003302509,0.0002779976,0.001259068],"category_scores_gemma":[0.0001419929,0.0001499467,0.0002135112,0.0001606012,0.0004026134,0.0003546983,0.0005614522,0.0004809462,0.0004918053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009413133,"about_ca_system_score_gemma":0.0003186925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001105853,"about_ca_topic_score_gemma":0.002758956,"domain_scores_codex":[0.9998236,0.00001493358,0.00000826459,0.00004486219,0.00004696216,0.00006139576],"domain_scores_gemma":[0.9998939,0.000006889101,0.00002708531,0.00001274079,0.0000146008,0.00004487583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081249,0.00001213086,0.00229122,0.00001937875,0.000007231881,0.0000970515,0.00003534361,0.0002310769,0.992059,0.001176703,0.0002011439,0.003761574],"study_design_scores_gemma":[0.0000137174,0.000124754,0.02226274,0.000008064876,0.00002056053,0.0002880723,0.0001365091,0.002710657,0.9656597,0.0004509761,0.008313534,0.00001071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862586,0.001954995,0.005993598,0.0004073761,0.00005793249,0.00001779816,0.0003054539,0.0003395261,0.004664777],"genre_scores_gemma":[0.9968676,0.0001531464,0.0007335261,0.00006967451,0.000008448584,0.000004347039,0.0001884855,0.00002333245,0.001951452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259068,"threshold_uncertainty_score":0.006829679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00868642609189877,"score_gpt":0.2469899583572469,"score_spread":0.2383035322653481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}