{"id":"W2179638825","doi":"10.1016/j.ccell.2015.10.005","title":"MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Structural Genomics Consortium; Toronto Western Hospital; Princess Margaret Cancer Centre; McGill University Health Centre; Ontario Institute for Cancer Research; University Health Network; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chromatin; Histone; Biology; Cell biology; Cancer; Histone H3; Cancer research; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001952542,0.0001763986,0.000141457,0.000007155917,0.0001160004,0.00008868911,0.0002235794,0.00009183014,0.00002032801],"category_scores_gemma":[0.00001401077,0.000140802,0.00003093905,0.00005752638,0.00007912678,0.000005986437,0.0001618778,0.00008056642,0.000001609523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150729,"about_ca_system_score_gemma":0.0003702791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001689853,"about_ca_topic_score_gemma":0.0005746985,"domain_scores_codex":[0.9990246,0.0000474923,0.0001963986,0.0003529017,0.0001191296,0.0002594412],"domain_scores_gemma":[0.9993201,0.000008378794,0.0001449883,0.0003088654,0.00008962077,0.0001279776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003020672,0.00004210919,0.0007650607,0.00004433048,0.00007241074,0.000006209125,0.0009576622,0.0004329809,0.9823043,0.00001532146,0.01367673,0.001652682],"study_design_scores_gemma":[0.003105109,0.0003798378,0.001140641,0.0001259944,0.0002642595,0.00009672439,0.001574361,0.007734058,0.8582954,0.0009769739,0.1250456,0.00126106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708009,0.02591207,0.0002596648,0.0003868746,0.000218074,0.0001476012,0.00008760963,0.00002190478,0.002165319],"genre_scores_gemma":[0.9930429,0.003631461,0.001232515,0.0003743537,0.0001541713,0.00003659083,0.00004925796,0.00003685715,0.001441894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1240089,"threshold_uncertainty_score":0.5741739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00868642609189877,"score_gpt":0.2469899583572469,"score_spread":0.2383035322653481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}