{"id":"W2179676503","doi":"10.1016/j.it.2015.11.002","title":"CTLA-4 and Autoimmunity: New Twists in the Tale","year":2015,"lang":"en","type":"letter","venue":"Trends in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Autoimmunity; CTLA-4; Immunology; Cre recombinase; Immune system; Biology; T cell; Gene; Genetics; Genetically modified mouse; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006616856,0.000856202,0.001833119,0.002187983,0.002343734,0.006498449,0.001624462,0.004759941,0.00571437],"category_scores_gemma":[0.00647183,0.0006668895,0.001137673,0.001397205,0.0120272,0.01320255,0.004987016,0.02024441,0.001502371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002035808,"about_ca_system_score_gemma":0.002911244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435404,"about_ca_topic_score_gemma":0.003219687,"domain_scores_codex":[0.9977076,0.000873928,0.0001233862,0.0002750113,0.0006115104,0.0004084879],"domain_scores_gemma":[0.9925622,0.004982524,0.0002629425,0.0003612297,0.0007125605,0.001118509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001150126,0.0002043798,0.003486714,0.00323378,0.000605405,0.003728891,0.008001619,0.001770885,0.008632724,0.4345879,0.1874607,0.3471368],"study_design_scores_gemma":[0.00009217997,0.0002154625,0.001535235,0.001290313,0.0001287158,0.001550451,0.004313065,0.0005896123,0.001646493,0.3576095,0.6308831,0.0001458386],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01258449,0.4603911,0.01448626,0.4705161,0.02390317,0.00002541339,0.0002653785,0.0004204024,0.01740772],"genre_scores_gemma":[0.2198239,0.5135445,0.01239803,0.1970601,0.03483256,0.0001116922,0.0003964719,0.000454471,0.02137834],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006616856,"threshold_uncertainty_score":0.03499371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936295530200967,"score_gpt":0.2613936413426948,"score_spread":0.2320306860406851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}