{"id":"W2179676503","doi":"10.1016/j.it.2015.11.002","title":"CTLA-4 and Autoimmunity: New Twists in the Tale","year":2015,"lang":"en","type":"letter","venue":"Trends in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Autoimmunity; CTLA-4; Immunology; Cre recombinase; Immune system; Biology; T cell; Gene; Genetics; Genetically modified mouse; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0008728579,0.000853237,0.001435778,0.00162114,0.0001537045,0.00005139678,0.001808872,0.004140989,0.001463787],"category_scores_gemma":[0.0001344538,0.0006683181,0.0001921219,0.0008952759,0.001718313,0.0001329219,0.0006410054,0.008084613,0.001016077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174237,"about_ca_system_score_gemma":0.0003371652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004999448,"about_ca_topic_score_gemma":0.00103062,"domain_scores_codex":[0.9942753,0.002139492,0.001024177,0.0009515533,0.0001007601,0.001508688],"domain_scores_gemma":[0.9972712,0.0006914117,0.0003932566,0.001558461,0.00006461501,0.00002101788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000200123,0.0002132509,0.0003694999,0.00002723811,0.0003406198,0.0007318435,0.003651468,9.353608e-7,0.05726464,0.0002812766,0.9016888,0.03523034],"study_design_scores_gemma":[0.004218492,0.0005096806,0.002320743,0.00007896902,0.00008637214,0.00175662,0.0004067004,8.76006e-7,0.001051081,0.001844859,0.9870432,0.0006824153],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1554521,0.1532122,0.000007922667,0.6485966,0.008258554,0.0008970955,0.0001531268,0.0003697106,0.03305271],"genre_scores_gemma":[0.4146892,0.004032096,0.0001510906,0.3159709,0.001316977,0.0003934188,0.007700604,0.0003446976,0.2554009],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3326257,"threshold_uncertainty_score":0.9997618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936295530200967,"score_gpt":0.2613936413426948,"score_spread":0.2320306860406851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}