{"id":"W2179775941","doi":"10.1039/c5ra19050a","title":"Codelivery of doxorubicin and p53 by biodegradable micellar carriers based on chitosan derivatives","year":2015,"lang":"en","type":"article","venue":"RSC Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"National Natural Science Foundation of China","keywords":"Chitosan; Doxorubicin; Micelle; Cationic polymerization; Chemistry; Combinatorial chemistry; Polymer chemistry; Organic chemistry; Chemotherapy; Aqueous solution; Surgery; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005985309,0.0001262954,0.0001417878,0.0000323324,0.0000342116,0.000009283576,0.0001110606,0.00006857572,0.000004070385],"category_scores_gemma":[0.00004183401,0.0001079041,0.0000356624,0.00005449283,0.0001292493,0.000008086556,0.000031308,0.00004385914,0.00000206922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004374784,"about_ca_system_score_gemma":0.00004927389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002821527,"about_ca_topic_score_gemma":0.00001487439,"domain_scores_codex":[0.999333,0.00003571276,0.0001324831,0.0002451834,0.0001082133,0.0001454229],"domain_scores_gemma":[0.9996021,0.00001458536,0.00007440705,0.0001776111,0.00004663023,0.00008465104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002077971,0.00004173539,0.00366166,0.00001905687,0.00002076341,0.000001128037,0.00005878818,0.0003809818,0.9904147,0.000007859348,0.002510946,0.002674629],"study_design_scores_gemma":[0.0004396711,0.0007354738,0.00008770601,0.00002658631,0.000009101362,0.000001248414,0.0005722939,0.000336361,0.9764901,0.000043507,0.02111838,0.0001395691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98568,0.01082355,0.001020266,0.00008667594,0.00009353208,0.00007916112,0.00007238343,0.000006801396,0.002137627],"genre_scores_gemma":[0.9976414,0.001024242,0.0007839581,0.0002562569,0.00004200865,0.000005586431,0.00007336697,0.000009870701,0.0001633144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01860744,"threshold_uncertainty_score":0.4400202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155099279138995,"score_gpt":0.2455263381560977,"score_spread":0.2339753453647077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}