{"id":"W2179846242","doi":"10.3233/jad-150482","title":"LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer’s Disease","year":2015,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Materials Research","keywords":"Cytotoxicity; Internalization; Transfection; Neurotoxicity; Extracellular; Senile plaques; Antibody; Molecular biology; Biology; Cell culture; Cell biology; Amyloid (mycology); Antibody-dependent cell-mediated cytotoxicity; Microglia; Chemistry; Cell; In vitro; Immunology; Alzheimer's disease; Biochemistry; Toxicity; Pathology; Medicine; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003139988,0.0004278476,0.0006029523,0.000329774,0.000173138,0.0002503607,0.0003329701,0.0003818974,0.0009484496],"category_scores_gemma":[0.0001784637,0.0002137974,0.0003658196,0.0002001516,0.000244169,0.0001859215,0.0002026385,0.0007010875,0.0005923305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058574,"about_ca_system_score_gemma":0.0001811649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000703626,"about_ca_topic_score_gemma":0.0007379337,"domain_scores_codex":[0.9997522,0.00006460389,0.00003456323,0.00002712066,0.00006615977,0.00005538405],"domain_scores_gemma":[0.9998608,0.00003280276,0.00002413668,0.00002558677,0.00002915952,0.00002747559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009185838,0.00004839595,0.00005648129,0.00004988684,0.000004790262,0.0001098229,0.00001117361,0.00001954066,0.9989696,0.00002866017,0.00002877753,0.000581065],"study_design_scores_gemma":[0.0000317026,0.0006810811,0.006014496,0.000009640039,0.00002909069,0.0007946509,0.00002092993,0.0006819949,0.9905955,0.00003069447,0.001104035,0.000006274664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99352,0.002942394,0.001549682,0.00008711571,0.00003205154,0.00003605387,0.0002118325,0.0001112121,0.001509562],"genre_scores_gemma":[0.9913228,0.001769754,0.00310642,0.00006478142,0.0000191551,0.00007940154,0.0007408254,0.00002286149,0.00287401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009484496,"threshold_uncertainty_score":0.003172934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684062318336971,"score_gpt":0.3271226173726389,"score_spread":0.2802819941892691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}