{"id":"W2180413537","doi":"10.1080/19336950.2015.1098793","title":"Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling","year":2015,"lang":"en","type":"article","venue":"Channels","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Canadian Institutes of Health Research","keywords":"Gating; Active zone; Synaptic vesicle; Biophysics; Chemistry; Calyx; Synapse; Vesicle; Anatomy; Biology; Neuroscience; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000635407,0.0002423963,0.0004283059,0.0005669339,0.0003688893,0.00005539445,0.0006397623,0.0001035524,0.00004058212],"category_scores_gemma":[0.0005254874,0.0002246071,0.00018726,0.002665343,0.0004045455,0.0003119328,0.0004773839,0.0002784159,0.00005139025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008519408,"about_ca_system_score_gemma":0.00005580967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002794139,"about_ca_topic_score_gemma":0.000004148436,"domain_scores_codex":[0.9967706,0.0004119145,0.0004374524,0.0008460557,0.0007752316,0.0007587662],"domain_scores_gemma":[0.9986445,0.000256814,0.000186387,0.000396809,0.0001274695,0.0003880616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000781679,0.0002027852,0.0001523624,0.00001792676,0.00002015145,0.00006547324,0.0006835822,0.01268489,0.9857942,0.00002296664,0.0002089135,0.00006860235],"study_design_scores_gemma":[0.0004457818,0.0002996039,0.000006374337,0.00001204439,0.00005710128,0.00002300516,0.00024041,0.2378139,0.7606578,0.0002472964,0.0000242251,0.0001723618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956646,0.0001111,0.002658322,0.0003407788,0.0004668995,0.0002868528,0.00003666108,0.00008789932,0.0003468983],"genre_scores_gemma":[0.999009,0.00003669104,0.00001618632,0.0004873692,0.00007035997,0.0000306314,0.000003384708,0.00003175374,0.0003146086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2251363,"threshold_uncertainty_score":0.9159213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1268521112638677,"score_gpt":0.3367383090678872,"score_spread":0.2098861978040195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}