{"id":"W2180718760","doi":"10.1136/bjophthalmol-2015-307000","title":"EP3/FP dual receptor agonist ONO-9054 administered morning or evening to patients with open-angle glaucoma or ocular hypertension: results of a randomised crossover study","year":2015,"lang":"en","type":"article","venue":"British Journal of Ophthalmology","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Evening; Morning; Open angle glaucoma; Crossover study; Glaucoma; Ocular hypertension; Agonist; Ophthalmology; Open label; Anesthesia; Internal medicine; Randomized controlled trial; Receptor; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00426459,0.001909007,0.006373479,0.0007245492,0.0007014688,0.001006903,0.001177836,0.00199078,0.006439664],"category_scores_gemma":[0.003782411,0.001113779,0.003317163,0.0008375722,0.001818648,0.001479055,0.0005035532,0.002306027,0.001076982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007612896,"about_ca_system_score_gemma":0.001355907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199992,"about_ca_topic_score_gemma":0.001829922,"domain_scores_codex":[0.9974968,0.001392067,0.0002692242,0.0003471296,0.0001879979,0.0003067839],"domain_scores_gemma":[0.9966002,0.001085455,0.0006349484,0.0004359507,0.0003008355,0.0009426171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9651008,0.01749539,0.0008674887,0.0004268799,0.0008379975,0.00006832437,0.0001115822,0.0001034514,0.005059016,0.00002748719,0.0002014887,0.009700067],"study_design_scores_gemma":[0.7277301,0.2659971,0.004576592,0.00002241749,0.0007213066,0.0000408156,0.00003945043,0.0001308704,0.0004007918,0.00004337665,0.0002733225,0.00002389251],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933553,0.002022596,0.0006261938,0.0001656652,0.0003582678,0.002336689,0.00045211,0.00004775934,0.0006355956],"genre_scores_gemma":[0.9898261,0.002373578,0.001672294,0.0005506225,0.0008916848,0.002444753,0.000761444,0.00003362113,0.001445778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006439664,"threshold_uncertainty_score":0.02255362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126923606068565,"score_gpt":0.3148027772652527,"score_spread":0.2635335412045671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}