{"id":"W2180740327","doi":"10.1016/j.bmcl.2003.12.032","title":"Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Chemistry; Benzimidazole; Polymerase; RNA polymerase; Potency; Hepatitis C virus; Enzyme; RNA-dependent RNA polymerase; Biochemistry; Nucleotidyltransferase; Virology; Nucleoside; Structure–activity relationship; Stereochemistry; RNA; Virus; Hepacivirus; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003208337,0.0005490243,0.0003589569,0.0001588389,0.0001254914,0.0002431016,0.0004569172,0.0003079888,0.001382852],"category_scores_gemma":[0.0002637289,0.0001849737,0.0002033308,0.00009632435,0.0001910478,0.00019551,0.0001798564,0.0005551912,0.0004371221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696504,"about_ca_system_score_gemma":0.0002669725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006571327,"about_ca_topic_score_gemma":0.002882461,"domain_scores_codex":[0.9999001,0.00001971407,0.000006280335,0.00001186059,0.00003284124,0.0000290515],"domain_scores_gemma":[0.9999169,0.00001868485,0.00001671739,0.000007375916,0.00001650219,0.0000238522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005687238,0.0002154574,0.0002986826,0.0002488364,0.00001967781,0.000336596,0.00005955574,0.0009148713,0.9622831,0.000921601,0.0005804609,0.03355228],"study_design_scores_gemma":[0.0007656951,0.006634481,0.003796955,0.00006226888,0.00007762662,0.001435595,0.00003591831,0.002983103,0.9594893,0.0003054711,0.02437002,0.00004354862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330876,0.03293481,0.01765352,0.0005732438,0.0002077209,0.0004128595,0.0006101296,0.0002875718,0.01423261],"genre_scores_gemma":[0.9688447,0.01388315,0.009412859,0.0003151342,0.00007378317,0.0001154138,0.0008686596,0.00003488535,0.006451493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382852,"threshold_uncertainty_score":0.004626095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005753133087768912,"score_gpt":0.2231402569191561,"score_spread":0.2173871238313872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}