{"id":"W2180824532","doi":"10.1081/ncn-120022848","title":"Synthesis and Physicochemical Properties of 2′-Deoxy- 2′,2″-difluoro-β-<scp>D</scp>-ribofuranosyl and 2′-Deoxy-2′,2″- difluoro-α-<scp>D</scp>-ribofuranosyl Oligonucleotides","year":2003,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Oligonucleotide; Stereochemistry; Nucleoside; Chemistry; RNA; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008703951,0.001811843,0.001940766,0.0003181894,0.0007494087,0.0004438493,0.001334395,0.001266572,0.00008048065],"category_scores_gemma":[0.004984361,0.001758132,0.0007536887,0.0006372784,0.002752597,0.0002118077,0.001029813,0.0009050157,0.00008746648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001127572,"about_ca_system_score_gemma":0.0002294846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008741224,"about_ca_topic_score_gemma":0.00001881249,"domain_scores_codex":[0.992175,0.0004133869,0.001794484,0.002504352,0.001027784,0.002084946],"domain_scores_gemma":[0.9946685,0.0007513281,0.0008986659,0.002032814,0.0005645923,0.001084122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009920734,0.0005794654,0.01133411,0.0008091344,0.0006844134,0.00003645416,0.001155613,0.00001558046,0.9726318,0.0009467381,0.009037514,0.002669957],"study_design_scores_gemma":[0.001867476,0.0005305656,0.006094291,0.0005118554,0.0005620284,0.0003467235,0.003724433,0.0001544186,0.9358515,0.0007252662,0.04893596,0.0006955163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807485,0.007648605,0.0000741268,0.0001817123,0.0003909956,0.0009073705,0.0002000386,0.0003298201,0.009518799],"genre_scores_gemma":[0.9899773,0.003032052,0.003789622,0.000634805,0.0005321003,0.0001414825,0.00007260434,0.0005147172,0.001305337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03989844,"threshold_uncertainty_score":0.9999613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008734736494421629,"score_gpt":0.2051543908850417,"score_spread":0.19641965439062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}