{"id":"W2180954358","doi":"10.1053/j.gastro.2015.10.050","title":"Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis","year":2015,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Genentech; Norgine; Astellas Pharma; Mitsubishi Tanabe Pharma Corporation; Celltrion; Danone; Ministère des Affaires Sociales et de la Santé; Therakos; Novo Nordisk; Teva Pharmaceutical Industries; UCB Pharma; Assistance publique-Hôpitaux de Paris; BioClinica; Abbott Laboratories; European Crohn's and Colitis Organisation; Biogen; Sanofi; Amgen; Dr. Falk Pharma; Vifor Pharma; Pfizer; IC Design Education Center; Eli Lilly and Company","keywords":"Medicine; Ulcerative colitis; Methotrexate; Prednisone; Placebo; Clinical endpoint; Gastroenterology; Internal medicine; Randomized controlled trial; Clinical trial; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438059,0.0002499493,0.001821012,0.0003996986,0.0002194647,0.0003189481,0.0001615382,0.0007185421,0.003739953],"category_scores_gemma":[0.003451095,0.0001274224,0.0006801228,0.0003649573,0.0002997315,0.0004781347,0.0001798163,0.000628754,0.0004833947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733222,"about_ca_system_score_gemma":0.0001747313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001711338,"about_ca_topic_score_gemma":0.0003450046,"domain_scores_codex":[0.999236,0.0004434705,0.00009266396,0.00006538728,0.00009625057,0.00006624763],"domain_scores_gemma":[0.9971077,0.001890299,0.0004166311,0.0001483213,0.0001013329,0.0003356402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3103231,0.002124612,0.09389392,0.002579517,0.003213801,0.001518771,0.0002727295,0.0004120402,0.08656893,0.0004653988,0.002817355,0.4958099],"study_design_scores_gemma":[0.06650922,0.1378862,0.7513345,0.0003709471,0.005189854,0.007751334,0.0003685428,0.0006694572,0.01244963,0.001066841,0.01633028,0.00007315476],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351946,0.05580327,0.0005582706,0.001787471,0.0003561474,0.0001256969,0.0002750428,0.00008414427,0.005815269],"genre_scores_gemma":[0.9937458,0.004449872,0.0002205015,0.0003979325,0.0004513193,0.00002062014,0.0001768095,0.000007829193,0.0005293144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003739953,"threshold_uncertainty_score":0.01251137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661833668539778,"score_gpt":0.2988882802337678,"score_spread":0.2722699435483701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}