{"id":"W2180954358","doi":"10.1053/j.gastro.2015.10.050","title":"Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis","year":2015,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Genentech; Norgine; Astellas Pharma; Mitsubishi Tanabe Pharma Corporation; Celltrion; Danone; Ministère des Affaires Sociales et de la Santé; Therakos; Novo Nordisk; Teva Pharmaceutical Industries; UCB Pharma; Assistance publique-Hôpitaux de Paris; BioClinica; Abbott Laboratories; European Crohn's and Colitis Organisation; Biogen; Sanofi; Amgen; Dr. Falk Pharma; Vifor Pharma; Pfizer; IC Design Education Center; Eli Lilly and Company","keywords":"Medicine; Ulcerative colitis; Methotrexate; Prednisone; Placebo; Clinical endpoint; Gastroenterology; Internal medicine; Randomized controlled trial; Clinical trial; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001052346,0.0002825243,0.0004495188,0.000133902,0.00005303918,0.00001761309,0.0004446144,0.0002878906,0.00001803534],"category_scores_gemma":[0.001272458,0.000240292,0.0001072813,0.00007776653,0.0001362242,0.00002323462,0.0004175271,0.0001917503,0.000002622978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006327433,"about_ca_system_score_gemma":0.0002156462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002069994,"about_ca_topic_score_gemma":0.0003639152,"domain_scores_codex":[0.9971021,0.0005543124,0.0008237906,0.0007091355,0.0002931439,0.0005174649],"domain_scores_gemma":[0.9978418,0.00003098613,0.0003644335,0.0008171826,0.0005642117,0.0003813239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06488721,0.0004556194,0.8920854,0.00008188262,0.0001188307,0.00003238198,0.0006527288,0.00004170426,0.03434872,0.000004873792,0.00640705,0.0008835576],"study_design_scores_gemma":[0.01695708,0.004809572,0.9482719,0.0001162276,0.00005907562,0.000008571675,0.0002728404,0.00005247676,0.02792734,0.0000602693,0.001221916,0.0002427206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961693,0.000006612142,0.001319772,0.0005130163,0.000230904,0.001329839,0.0003905414,0.0000130336,0.00002697504],"genre_scores_gemma":[0.9924715,0.000003908543,0.005507674,0.001268967,0.000142958,0.0001941382,0.0002114236,0.00004472254,0.0001547483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05618646,"threshold_uncertainty_score":0.9798823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02661833668539778,"score_gpt":0.2988882802337678,"score_spread":0.2722699435483701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}