{"id":"W2181049502","doi":"10.1016/s0223-5234(02)01414-9","title":"Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds","year":2002,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Purdue University","keywords":"Chemistry; Propenyl; Aryl; Stereochemistry; Cytotoxicity; Quantitative structure–activity relationship; Structure–activity relationship; Chemical synthesis; In vitro; Medicinal chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534756,0.000389434,0.0002968362,0.0003259575,0.0002247326,0.000182737,0.0003895532,0.0002304801,0.002904382],"category_scores_gemma":[0.0001602379,0.0001639141,0.000178578,0.0002143498,0.0002373079,0.0002126099,0.0002202285,0.0005380638,0.0006495856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110711,"about_ca_system_score_gemma":0.0002816783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000603353,"about_ca_topic_score_gemma":0.001739268,"domain_scores_codex":[0.9999036,0.00001869351,0.000007698341,0.00001484326,0.00002562269,0.00002955883],"domain_scores_gemma":[0.9999175,0.00002023063,0.00002071471,0.00001581073,0.000008726079,0.00001704083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001104072,0.0003212064,0.0002749641,0.000435033,0.00001839288,0.0003280571,0.00009101071,0.001310287,0.9669628,0.002203202,0.001708401,0.02524252],"study_design_scores_gemma":[0.000365131,0.003860502,0.004322673,0.00004226117,0.00005371678,0.001120475,0.00005620051,0.001127644,0.9515025,0.0004872274,0.0370418,0.00001978747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9345973,0.02204838,0.007324105,0.0006481521,0.0003079261,0.0002704991,0.001913966,0.0005620566,0.03232754],"genre_scores_gemma":[0.9745423,0.008452825,0.002533141,0.0001247154,0.00006732082,0.0001748552,0.001438512,0.00003233524,0.01263402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002904382,"threshold_uncertainty_score":0.009716153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0234141438946914,"score_gpt":0.2076304747020546,"score_spread":0.1842163308073632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}