{"id":"W2181253238","doi":"10.1128/mbio.01435-15","title":"Insufficient Acidification of Autophagosomes Facilitates Group A Streptococcus Survival and Growth in Endothelial Cells","year":2015,"lang":"en","type":"article","venue":"mBio","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Bafilomycin; Autophagy; Cell biology; Internalization; Lysosome; Microbiology; Streptolysin; Biology; Chemistry; Bacteria; Biochemistry; Cell; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119962,0.00009511934,0.0001964002,0.000120273,0.00001776592,0.000008092347,0.00002713353,0.0000517925,0.00002490162],"category_scores_gemma":[0.00006281382,0.00007661122,0.00003682762,0.0001686825,0.00007244684,0.00004631598,0.00002236455,0.00006059825,0.00001988557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006256246,"about_ca_system_score_gemma":0.00003796451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005950936,"about_ca_topic_score_gemma":0.00003270721,"domain_scores_codex":[0.9993263,0.00003383544,0.0002038172,0.000181463,0.0001290405,0.0001255506],"domain_scores_gemma":[0.9996065,0.00004635643,0.00004964841,0.0001287671,0.00007155668,0.00009713745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001020134,0.0009604255,0.9614099,0.00005187132,0.00004082347,0.00001252793,0.0008614642,0.000003459693,0.03198458,0.001199681,0.00004080123,0.003332449],"study_design_scores_gemma":[0.00431939,0.0009301626,0.8865041,0.00004750409,0.00004073175,0.000006345473,0.0006320499,0.0001553225,0.1063409,0.0004409903,0.0004787379,0.0001038665],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976367,0.0001395538,0.00005318554,0.00006915549,0.0001311704,0.0004596821,0.00005260754,0.00002786249,0.001430121],"genre_scores_gemma":[0.9995205,0.00002511074,0.0001645539,0.000008692058,0.00002231156,0.00005568707,0.00002310014,0.000006654393,0.0001734214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07490588,"threshold_uncertainty_score":0.3124115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03559143127881267,"score_gpt":0.2821141589880178,"score_spread":0.2465227277092051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}