{"id":"W2181342396","doi":"10.3389/fmicb.2015.01244","title":"Inside the Envelope: Endogenous Retrovirus-K Env as a Biomarker and Therapeutic Target","year":2015,"lang":"en","type":"review","venue":"Frontiers in Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Winnipeg","funders":"University of Winnipeg","keywords":"Endogenous retrovirus; Biology; Epigenetics; Innate immune system; Biomarker; Virology; Disease; Gene silencing; Retrovirus; Genome; Genetics; Gene; Immunology; Immune system; Virus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004560204,0.000451789,0.0009275765,0.000150804,0.00006094522,0.00002177091,0.0004422371,0.0006987666,0.000015021],"category_scores_gemma":[0.0000751848,0.0003188699,0.0001678523,0.0001969076,0.0002584975,0.000001368011,0.0002716582,0.0003466224,0.00001745215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005825923,"about_ca_system_score_gemma":0.0003125991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001948754,"about_ca_topic_score_gemma":0.00001212616,"domain_scores_codex":[0.9981549,0.0003107779,0.0004318899,0.0006022286,0.00004366358,0.0004565158],"domain_scores_gemma":[0.9991831,0.00002699146,0.0001389038,0.0005317169,0.00004296496,0.00007628165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005572612,0.0000414024,0.0001604639,0.001069936,0.0006937969,0.00004162777,0.0001698484,0.000006085842,0.02143108,0.00001146843,0.03237386,0.9439447],"study_design_scores_gemma":[0.0002611757,0.0001261601,0.000006125299,0.0001736556,0.0001357096,0.0006987478,0.00005165155,0.00000327985,0.000643093,0.00006311887,0.9974673,0.000369967],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001782146,0.9964224,0.001127041,0.00002571026,0.000968358,0.0006054433,0.00009158614,0.00001143756,0.0005698723],"genre_scores_gemma":[0.0006145483,0.9963144,0.001658984,0.0002144975,0.0001642658,0.00008625192,0.0004702038,0.0000677543,0.0004090863],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9650934,"threshold_uncertainty_score":0.9999263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727623020795097,"score_gpt":0.3067871858984882,"score_spread":0.2795109556905373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}