{"id":"W2181542557","doi":"10.1038/nature15742","title":"Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells","year":2015,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Biology; Carcinogenesis; KRAS; Context (archaeology); Phenotype; Cancer research; Progenitor cell; Human breast; Oncogene; Cell; Cancer; Cancer cell; Mutation; Genetics; Stem cell; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276061,0.00007951392,0.000161116,0.0005034354,0.0001816076,0.000616974,0.000234397,0.0002941161,0.001260025],"category_scores_gemma":[0.0006756506,0.0001757553,0.0001134641,0.0004166635,0.0001679511,0.0003049533,0.0003093751,0.0004298595,0.0003885894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003361016,"about_ca_system_score_gemma":0.0001534484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204535,"about_ca_topic_score_gemma":0.001700839,"domain_scores_codex":[0.9998423,0.00001054385,0.000008150979,0.00003986184,0.00006536471,0.00003388739],"domain_scores_gemma":[0.9994287,0.0002140436,0.0001077109,0.00008050594,0.0001138218,0.0000552356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008365172,0.00001110132,0.003127635,0.00001462791,0.000006469065,0.00009825413,0.00007958859,0.0004242124,0.9904413,0.0007454286,0.00008946285,0.004878303],"study_design_scores_gemma":[0.00001709568,0.0001890328,0.1590957,0.00001112178,0.0000430531,0.001577951,0.0003270873,0.02502308,0.8052222,0.001447656,0.007015854,0.00003008152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949444,0.0004208608,0.003097732,0.0000524864,0.00001050533,0.000007583583,0.0003804213,0.00006226682,0.001023748],"genre_scores_gemma":[0.9967682,0.0001944108,0.001168834,0.00002688368,0.000006174002,0.000008604925,0.0006576342,0.00003319547,0.001136136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260025,"threshold_uncertainty_score":0.004215181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742378409342351,"score_gpt":0.3233975718853534,"score_spread":0.2859737877919299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}