{"id":"W2182117355","doi":"10.1101/001883","title":"Tracking global changes induced in the CD4 T cell receptor repertoire by immunisation with a complex antigen using local sequence features of CDR3 protein sequence","year":2014,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Repertoire; Sequence (biology); Computational biology; Biology; Antigen; Tracking (education); Genetics; Sociology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580934,0.0001469247,0.0002029231,0.0003565659,0.0001034398,0.000233291,0.00009438203,0.0001962816,0.0004738692],"category_scores_gemma":[0.0002164588,0.0001078515,0.000128496,0.0002160874,0.0001490009,0.0001223124,0.000159381,0.0002971182,0.0001462954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001328254,"about_ca_system_score_gemma":0.00006065475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003904324,"about_ca_topic_score_gemma":0.0005688179,"domain_scores_codex":[0.9998605,0.00001822985,0.000006425814,0.00004452766,0.00003919611,0.00003103911],"domain_scores_gemma":[0.9998112,0.0000504799,0.00005906907,0.0000212062,0.00002487341,0.00003306183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005472126,0.000009031182,0.002880803,0.00001256386,0.000005941502,0.000006906042,0.00001131744,0.0001684196,0.9956568,0.000007236731,0.000006204555,0.001180051],"study_design_scores_gemma":[0.000009363077,0.00058469,0.2602033,0.000007956243,0.00004399719,0.0002460979,0.00009599171,0.01382336,0.7244786,0.00009017312,0.0004054268,0.00001112285],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974251,0.00007582569,0.002238169,0.000005226556,0.000001407044,0.000005108507,0.00009817121,0.0000281921,0.0001228047],"genre_scores_gemma":[0.9960845,0.00007031197,0.003293131,0.00001684634,0.000002125683,0.00001437636,0.0002337014,0.00001006508,0.0002748491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004738692,"threshold_uncertainty_score":0.001585186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291690989644729,"score_gpt":0.2423301236704933,"score_spread":0.209413213774046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}