{"id":"W2182302719","doi":"10.1016/s0026-895x(24)05619-0","title":"Agonist-Induced Internalization of Leukotriene B4 Receptor 1 Requires G-Protein-Coupled Receptor Kinase 2 but Not Arrestins","year":2004,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Internalization; Beta adrenergic receptor kinase; G protein-coupled receptor; G protein-coupled receptor kinase; Cell biology; Receptor; HEK 293 cells; Leukotriene B4; Biology; Agonist; Leukotriene receptor; Chemistry; Signal transduction; Biochemistry; Inflammation; Immunology; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003187089,0.0003515874,0.0003829827,0.0001348508,0.0001193587,0.00002730803,0.0004461246,0.0003473102,0.0007818738],"category_scores_gemma":[0.000148178,0.0003703068,0.0002330155,0.000215021,0.0001319888,0.0000123979,0.0002026609,0.0002159242,0.00004485081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008859502,"about_ca_system_score_gemma":0.0002674209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001507966,"about_ca_topic_score_gemma":0.000009104022,"domain_scores_codex":[0.9977756,0.0001942364,0.0005940939,0.0006634684,0.000280483,0.0004920772],"domain_scores_gemma":[0.9987879,0.00001369952,0.000355378,0.0003789738,0.000266912,0.0001970949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005287187,0.0001926298,0.00001502005,0.00004815457,0.0001579633,0.00002778059,0.0000610681,0.001097319,0.9958017,0.0009458545,0.0002913276,0.0008323891],"study_design_scores_gemma":[0.002440237,0.0008863448,0.00000942197,0.00005662673,0.00006002386,0.00001241903,0.00003684842,0.000152553,0.9896927,0.0002453774,0.00603357,0.0003739163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9314798,0.0003901149,0.06593278,0.000337327,0.0009330511,0.0007234123,0.00003724244,0.00004171895,0.000124604],"genre_scores_gemma":[0.9940122,0.0001117308,0.003891837,0.000830561,0.0004152154,0.0001791221,0.000273551,0.00007819544,0.0002075429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0625325,"threshold_uncertainty_score":0.9998749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469820209445474,"score_gpt":0.2733778939272636,"score_spread":0.2586796918328089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}