{"id":"W2182708897","doi":"10.1158/1078-0432.ccr-15-0481","title":"Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University; Princess Margaret Cancer Centre","funders":"National Cancer Institute; F. Hoffmann-La Roche","keywords":"Medicine; Leukemia; Chronic lymphocytic leukemia; Internal medicine; Refractory (planetary science); Oncology; Clinical trial; Adverse effect; Chronic myelogenous leukemia; Pharmacodynamics; Acute promyelocytic leukemia; Acute lymphocytic leukemia; Pharmacokinetics; Immunology; Pharmacology; Cancer research; Biology; Retinoic acid; Lymphoblastic Leukemia; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.006728937,0.0001382011,0.0006576652,0.0001928218,0.00004080585,0.00001088772,0.0004756591,0.0003006631,0.0000408824],"category_scores_gemma":[0.008633126,0.0000997211,0.0002924308,0.001187765,0.001048969,0.00002771617,0.0003182906,0.001530502,0.00001431472],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006636143,"about_ca_system_score_gemma":0.00676373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003363963,"about_ca_topic_score_gemma":0.001299703,"domain_scores_codex":[0.9954587,0.0009337211,0.001396281,0.000484838,0.001252639,0.0004737818],"domain_scores_gemma":[0.9968166,0.0006780254,0.0002726377,0.001079206,0.0008078238,0.0003456771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8376061,0.005837168,0.003405222,0.0004209371,0.0003335304,0.0003655342,0.001237982,0.0002195409,0.05262902,0.0003838402,0.0551641,0.04239699],"study_design_scores_gemma":[0.7394572,0.01681493,0.003627224,0.001565941,0.0001686459,0.00002031961,0.0005203425,0.00146643,0.1857349,0.000422336,0.04986278,0.0003389526],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856743,0.00102297,0.00001461572,0.002442824,0.0006118849,0.001582631,0.00009660548,0.00001393919,0.008540246],"genre_scores_gemma":[0.9979301,0.0004308169,0.00006457312,0.0001378165,0.0004220761,0.0001023425,0.00001469544,0.00003288718,0.0008646917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1331058,"threshold_uncertainty_score":0.9997176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.402294990732033,"score_gpt":0.5563611615816644,"score_spread":0.1540661708496314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}