{"id":"W2182708897","doi":"10.1158/1078-0432.ccr-15-0481","title":"Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University; Princess Margaret Cancer Centre","funders":"National Cancer Institute; F. Hoffmann-La Roche","keywords":"Medicine; Leukemia; Chronic lymphocytic leukemia; Internal medicine; Refractory (planetary science); Oncology; Clinical trial; Adverse effect; Chronic myelogenous leukemia; Pharmacodynamics; Acute promyelocytic leukemia; Acute lymphocytic leukemia; Pharmacokinetics; Immunology; Pharmacology; Cancer research; Biology; Retinoic acid; Lymphoblastic Leukemia; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001172897,0.001038704,0.001510675,0.0002751311,0.0002865362,0.0005033967,0.0004642668,0.000674705,0.002182721],"category_scores_gemma":[0.000839854,0.0002759931,0.000784958,0.0002371012,0.0004831055,0.0003993275,0.0002180885,0.00167811,0.0005259845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004940206,"about_ca_system_score_gemma":0.0008785638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005416134,"about_ca_topic_score_gemma":0.0008131454,"domain_scores_codex":[0.9995554,0.0002310859,0.00003430222,0.00005418517,0.00004935117,0.00007560553],"domain_scores_gemma":[0.9993008,0.000145885,0.0001367867,0.0000718173,0.00005443995,0.0002902211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6357843,0.03784685,0.01396338,0.0009630044,0.001667417,0.0004631403,0.0002222133,0.004317299,0.1257879,0.0002614406,0.007725942,0.1709972],"study_design_scores_gemma":[0.3147957,0.6230052,0.03533046,0.00006780027,0.001076972,0.0008407464,0.0000471744,0.00146195,0.01787504,0.000237216,0.005224814,0.00003698582],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991033,0.003304706,0.0007190406,0.0004194079,0.00008458115,0.001189119,0.00145512,0.0001017927,0.001693209],"genre_scores_gemma":[0.9912686,0.001586731,0.001028805,0.0004866041,0.0001219109,0.0006831385,0.00350803,0.0000251251,0.001290938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002182721,"threshold_uncertainty_score":0.007301927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.402294990732033,"score_gpt":0.5563611615816644,"score_spread":0.1540661708496314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}