{"id":"W2182716270","doi":"","title":"In vitro investigation of the hepatic extraction of RSD1070, a novel antiarrhythmic compound.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Microsome; Chemistry; Bioavailability; Free fraction; Pharmacokinetics; Metabolism; Extraction ratio; Chromatography; In vitro; Extraction (chemistry); Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003204944,0.0004697559,0.0004506752,0.0002163249,0.0001321116,0.0003625356,0.0001565977,0.0002011535,0.0007069993],"category_scores_gemma":[0.0003876839,0.0001420881,0.000298036,0.0002347344,0.0002162305,0.0002361113,0.0001473673,0.0004197307,0.0005477272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070119,"about_ca_system_score_gemma":0.0003575464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018518,"about_ca_topic_score_gemma":0.001137091,"domain_scores_codex":[0.9998044,0.00006866863,0.00001483065,0.00003662666,0.00005189019,0.00002362572],"domain_scores_gemma":[0.9997455,0.00009841433,0.00006204613,0.00003476631,0.00004114388,0.00001803195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007054827,0.00007198915,0.0008870694,0.0002544222,0.00004769286,0.0001644601,0.00002814628,0.0006101596,0.985694,0.000104554,0.0002060217,0.01122598],"study_design_scores_gemma":[0.00004065837,0.001513327,0.004545619,0.00001410185,0.00009953028,0.0008919097,0.00002429597,0.003183825,0.9864232,0.00004960093,0.003203915,0.00001009333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566086,0.01698638,0.02118577,0.0002676366,0.00008671347,0.0001434242,0.00133906,0.0001945305,0.003187878],"genre_scores_gemma":[0.981358,0.00711272,0.007684866,0.0001202113,0.00004574029,0.00006826407,0.001838663,0.00004574047,0.001725796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018518,"threshold_uncertainty_score":0.002953053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01726321637382348,"score_gpt":0.2380798480454978,"score_spread":0.2208166316716743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}