{"id":"W218273434","doi":"10.1182/blood.v124.21.714.714","title":"Primary Analysis Results from an Open-Label Phase II Study of INCB039110, a Selective JAK1 Inhibitor, in Patients with Myelofibrosis","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of British Columbia; St. Paul's Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Myelofibrosis; Medicine; Internal medicine; Ruxolitinib; Clinical endpoint; Polycythemia vera; Gastroenterology; Constitutional symptoms; Essential thrombocythemia; Anemia; Bone pain; Phases of clinical research; Extramedullary hematopoiesis; Abdominal pain; Bone marrow; Clinical trial; Disease; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005144268,0.001192696,0.002453378,0.00032812,0.0004435443,0.001100092,0.0005543937,0.0008083323,0.005904672],"category_scores_gemma":[0.002771333,0.0004504764,0.002122392,0.0004094826,0.0005756944,0.0006968898,0.0003686757,0.001649737,0.00101928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000824888,"about_ca_system_score_gemma":0.001323864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005364228,"about_ca_topic_score_gemma":0.001172022,"domain_scores_codex":[0.9981989,0.001044984,0.0001378246,0.0002536351,0.0002094252,0.0001552115],"domain_scores_gemma":[0.9970877,0.0009971621,0.00063642,0.0002629618,0.0003623712,0.0006534475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8787327,0.01293716,0.01501353,0.001602625,0.005731477,0.0002030256,0.000111886,0.001430764,0.01818689,0.0001418528,0.005107718,0.06080034],"study_design_scores_gemma":[0.598702,0.2932338,0.08643034,0.0001614979,0.006140139,0.0005517596,0.00006961734,0.00166504,0.005911083,0.0002891067,0.006789178,0.00005663348],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612969,0.01214595,0.00299844,0.0007634453,0.0002080923,0.006408602,0.009725122,0.0002047053,0.006248769],"genre_scores_gemma":[0.981811,0.001774913,0.002166494,0.0009627158,0.0002095247,0.002989666,0.007877584,0.00004560587,0.002162399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005904672,"threshold_uncertainty_score":0.02720582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629153354201179,"score_gpt":0.2901397847878001,"score_spread":0.2738482512457883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}